Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.

Niemann-pick type C1 (NPC1) is an endo/lysosomal membrane protein involved in intracellular cholesterol trafficking, and its luminal domain C is an essential endosomal receptor for Ebola and Marburg viruses. We have determined the crystal structure of glycosylated NPC1 luminal domain C and find all...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Zhao, Y, Ren, J, Harlos, K, Stuart, D
Format:	Journal article
Język:	English
Wydane:	Wiley 2016

Podobne zapisy

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
od: Piyali Saha, i wsp.
Wydane: (2020-05-01)

Identification and Classification of Rare Variants in NPC1 and NPC2 in Quebec
od: Lahoud Touma, i wsp.
Wydane: (2021-05-01)

Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1&#8217;s Function as a Filovirus Entry Receptor
od: Esther Ndungo, i wsp.
Wydane: (2012-10-01)

The NPC pathway and persistence of intracellular pathogens
od: Weng, Y
Wydane: (2023)

MemoryRepository for AI NPC
od: Shijie Zheng, i wsp.
Wydane: (2024-01-01)

Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease.
od: Blair R Roszell, i wsp.
Wydane: (2013-01-01)

Utility of primary cells to examine NPC1 receptor expression in Mops condylurus, a potential Ebola virus reservoir.
od: Marcel Bokelmann, i wsp.
Wydane: (2020-01-01)

An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor
od: Irfan Ahmad, i wsp.
Wydane: (2023-12-01)

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies
od: Zachary A. Bornholdt, i wsp.
Wydane: (2016-03-01)

LMP-1 and Nasopharyngeal Carcinoma (NPC)
od: Anggun Indah Budiningrum, i wsp.
Wydane: (2014-06-01)

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
od: Feiran Lu, i wsp.
Wydane: (2015-12-01)

AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease
od: Chang Xie, i wsp.
Wydane: (2017-03-01)

Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations
od: Charina M. Ramirez, i wsp.
Wydane: (2011-04-01)

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts
od: Newton, J, i wsp.
Wydane: (2017)

Nasopharyngeal carcinoma (NPC) with liver metastasis in pregnancy
od: Zakaria, Atiqah Farah, i wsp.
Wydane: (2016)

The role of NPC1L1 in cancer
od: Renshuai Zhang, i wsp.
Wydane: (2022-08-01)

New Active-Stacked-NPC Multilevel Converter
od: Dan Floricau, i wsp.
Wydane: (2009-10-01)

The NPC Families Mediate BmNPV Entry
od: Youpeng Fan, i wsp.
Wydane: (2022-08-01)

The structure of the NPC1L1 N-terminal domain in a closed conformation.
od: Hyock Joo Kwon, i wsp.
Wydane: (2011-04-01)

Prognostic significance of high NPC2 expression in gastric cancer
od: Yunzhuang Yao, i wsp.
Wydane: (2023-11-01)

Niemann-Pick Disease Type C (NPDC) by Mutation of <i>NPC1</i> and <i>NPC2</i>: Aberrant Lysosomal Cholesterol Trafficking and Oxidative Stress
od: Dongun Lee, i wsp.
Wydane: (2023-11-01)

Design and development of neutral-point clamped (NPC) inverter
od: Shan, Yuqing
Wydane: (2020)

Refinements of the Hermite–Hadamard Inequality in NPC Global Spaces
od: Conde Cristian
Wydane: (2018-09-01)

Integrated Control and Modulation for Three-Level NPC Rectifiers
od: Antonio Ventosa-Cutillas, i wsp.
Wydane: (2019-04-01)

Structural basis for itraconazole-mediated NPC1 inhibition
od: Tao Long, i wsp.
Wydane: (2020-01-01)

Clinical and neurophysiological characteristics of heterozygous NPC1 carriers
od: Alberto Benussi, i wsp.
Wydane: (2019-09-01)

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
od: Leslie A McCauliff, i wsp.
Wydane: (2019-10-01)

Interaction of functional <it>NPC1 </it>gene Polymorphism with smoking on coronary heart disease
od: Hui Rutai, i wsp.
Wydane: (2010-10-01)

Evaluation of the landscape of pharmacodynamic biomarkers in Niemann-Pick Disease Type C (NPC)
od: Sydney Stern, i wsp.
Wydane: (2024-07-01)

Severe neurometabolic phenotype in npc1−/− zebrafish with a C-terminal mutation
od: Ana Quelle-Regaldie, i wsp.
Wydane: (2023-03-01)

Olfactory deficits in Niemann-Pick type C1 (NPC1) disease.
od: Marina Hovakimyan, i wsp.
Wydane: (2013-01-01)

Toremifene interacts with and destabilizes the Ebola virus glycoprotein
od: Zhao, Y, i wsp.
Wydane: (2016)

Toremifene interacts with and destabilizes the Ebola virus glycoprotein.
od: Zhao, Y, i wsp.
Wydane: (2016)

Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice.
od: Raffaella Melzi, i wsp.
Wydane: (2010-04-01)

Nonparametric Combination (NPC): A Framework for Testing Elaborate Theories
od: Caughey, Devin, i wsp.
Wydane: (2018)

Nonparametric combination (NPC): a framework for testing elaborate theories
od: Caughey, D, i wsp.
Wydane: (2017)

Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential
od: Madhan Krishnan, i wsp.
Wydane: (2024-09-01)

The Role of NK Cells in EBV Infection and EBV-Associated NPC
od: Yi Tian Png, i wsp.
Wydane: (2021-02-01)

The politics of the NPC meme: Reactionary subcultural practice and vernacular theory
od: Rob Gallagher, i wsp.
Wydane: (2023-01-01)

Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia.
od: Maarten A Wildeman, i wsp.
Wydane: (2013-01-01)