A NEW BASE-STABLE LINKER FOR SOLID-PHASE OLIGONUCLEOTIDE SYNTHESIS
The succinyl-sarcosyl linker (1b), which is stable to prolonged contact with 1,8-diazabicyclo[5.4.0]undec-7-ene but cleaves rapidly with aqueous ammonia, is of potential value in solid-phase oligonucleotide synthesis.
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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| Summary: | The succinyl-sarcosyl linker (1b), which is stable to prolonged contact with 1,8-diazabicyclo[5.4.0]undec-7-ene but cleaves rapidly with aqueous ammonia, is of potential value in solid-phase oligonucleotide synthesis. |
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