T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine
IL-23 is a key driver of pathogenic Th17 cell responses. It has been suggested that the transcription factor T-bet is required to facilitate IL-23-driven pathogenic effector functions; however, the precise role of T-bet in intestinal T cell responses remains elusive. Here, we show that T-bet express...
Main Authors: | Krausgruber, T, Schiering, C, Adelmann, K, Harrison, O, Chomka, A, Pearson, C, Ahern, P, Shale, M, Oukka, M, Powrie, F |
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Format: | Journal article |
Published: |
Nature Publishing Group
2016
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