Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants.
<h4>Objective</h4> <p>Factors associated with poor health in HIV-exposed-uninfected (HEU) infants are poorly defined.Wedescribe the prevalence and correlates of cytomegalovirus (CMV) viraemia in HEU and HIV-unexposed-uninfected (HUU) infants, and quantify associations with anthrop...
| প্রধান লেখক: | , , , , , , , , , , |
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| বিন্যাস: | Journal article |
| ভাষা: | English |
| প্রকাশিত: |
Lippincott, Williams & Wilkins
2017
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| _version_ | 1826267899940044800 |
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| author | Garcia-Knight, M Nduati, E Hassan, A Nkumama, I Etyang, T Hajj, N Gambo, F Odera, D Berkley, J Rowland-Jones, S Urban, B |
| author_facet | Garcia-Knight, M Nduati, E Hassan, A Nkumama, I Etyang, T Hajj, N Gambo, F Odera, D Berkley, J Rowland-Jones, S Urban, B |
| author_sort | Garcia-Knight, M |
| collection | OXFORD |
| description | <h4>Objective</h4> <p>Factors associated with poor health in HIV-exposed-uninfected (HEU) infants are poorly defined.Wedescribe the prevalence and correlates of cytomegalovirus (CMV) viraemia in HEU and HIV-unexposed-uninfected (HUU) infants, and quantify associations with anthropometric, haematological, and immunological outcomes.</p> <h4>Design</h4> <p>Cross-sectional, including HEU and HUU infants from rural coastal Kenya.</p> <h4>Methods</h4> <p>Infants aged 2–8 months were studied. The primary outcome was CMV viraemia and viral load, determined by quantitative PCR. Correlates were tested by logistic and linear regression; coefficients were used to describe associations between CMV viraemia and clinical/immunological parameters.</p> <h4>Results</h4> <p>In total, 42 of 65 (64.6%) infants had CMV viraemia [median viral load, 3.0 (interquartile ranges: 2.7–3.5) log10 IU/ml]. Compared to community controls, HEU infants had six-fold increased odds of being viraemic (adjusted odds ratio 5.95 [95% confidence interval: 1.82–19.36], P=0.003). Age, but not HEU/HUU status, was a strong correlate of CMV viral load (coefficient=-0.15, P=0.009). CMV viral load associated negatively with weight-for-age (WAZ) Z-score (coefficient= -1.06, P=0.008) and head circumference-for-age Z-score (coefficient= -1.47, P=0.012) and positively with CD8þ T-cell coexpression of CD38/human leucocyte antigen DR (coefficient=15.05, P=0.003).</p> <h4>Conclusion</h4> <p>The odds of having CMV viraemia was six-fold greater in HEU than HUU infants when adjusted for age. CMV viral load was associated with adverse growth and heightened CD8þ T-cell immune activation. Longitudinal assessments of the clinical effects of primary CMV infection and associated immunomodulation in early life in HEU and HUU populations are warranted.</p> |
| first_indexed | 2024-03-06T21:01:20Z |
| format | Journal article |
| id | oxford-uuid:3afb0e9e-c7de-40f6-9419-82e9529ece60 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:01:20Z |
| publishDate | 2017 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:3afb0e9e-c7de-40f6-9419-82e9529ece602022-03-26T14:04:53ZCytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3afb0e9e-c7de-40f6-9419-82e9529ece60EnglishSymplectic Elements at OxfordLippincott, Williams & Wilkins2017Garcia-Knight, MNduati, EHassan, ANkumama, IEtyang, THajj, NGambo, FOdera, DBerkley, JRowland-Jones, SUrban, B <h4>Objective</h4> <p>Factors associated with poor health in HIV-exposed-uninfected (HEU) infants are poorly defined.Wedescribe the prevalence and correlates of cytomegalovirus (CMV) viraemia in HEU and HIV-unexposed-uninfected (HUU) infants, and quantify associations with anthropometric, haematological, and immunological outcomes.</p> <h4>Design</h4> <p>Cross-sectional, including HEU and HUU infants from rural coastal Kenya.</p> <h4>Methods</h4> <p>Infants aged 2–8 months were studied. The primary outcome was CMV viraemia and viral load, determined by quantitative PCR. Correlates were tested by logistic and linear regression; coefficients were used to describe associations between CMV viraemia and clinical/immunological parameters.</p> <h4>Results</h4> <p>In total, 42 of 65 (64.6%) infants had CMV viraemia [median viral load, 3.0 (interquartile ranges: 2.7–3.5) log10 IU/ml]. Compared to community controls, HEU infants had six-fold increased odds of being viraemic (adjusted odds ratio 5.95 [95% confidence interval: 1.82–19.36], P=0.003). Age, but not HEU/HUU status, was a strong correlate of CMV viral load (coefficient=-0.15, P=0.009). CMV viral load associated negatively with weight-for-age (WAZ) Z-score (coefficient= -1.06, P=0.008) and head circumference-for-age Z-score (coefficient= -1.47, P=0.012) and positively with CD8þ T-cell coexpression of CD38/human leucocyte antigen DR (coefficient=15.05, P=0.003).</p> <h4>Conclusion</h4> <p>The odds of having CMV viraemia was six-fold greater in HEU than HUU infants when adjusted for age. CMV viral load was associated with adverse growth and heightened CD8þ T-cell immune activation. Longitudinal assessments of the clinical effects of primary CMV infection and associated immunomodulation in early life in HEU and HUU populations are warranted.</p> |
| spellingShingle | Garcia-Knight, M Nduati, E Hassan, A Nkumama, I Etyang, T Hajj, N Gambo, F Odera, D Berkley, J Rowland-Jones, S Urban, B Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants. |
| title | Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants. |
| title_full | Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants. |
| title_fullStr | Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants. |
| title_full_unstemmed | Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants. |
| title_short | Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants. |
| title_sort | cytomegalovirus viraemia is associated with poor growth and t cell activation with an increased burden in hiv exposed uninfected infants |
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