Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation
Multiple Sclerosis, a chronic inflammatory demyelinating disease of the central nervous system, involves increased expression of monocyte chemotactic protein 1 MCP1-/CCL2. For exerting its chemotactic effects, chemokine binding to glycosaminoglycans (GAGs) is required and therefore this interaction...
Main Authors: | Gschwandtner, M, Piccinini, A, Gerlza, T, Adage, T, Kungl, A |
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Format: | Journal article |
Language: | English |
Published: |
Elsevier
2016
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