Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study
Interleukin-17A (IL-17) is a pro-inflammator¬y cytokine, which has been reported to be increased in the joint of patients with OA. This study aimed to identify whether IL-17 or its receptors are expressed in the joints of OA patients and establish the effect of IL-17 in vitro on primary human chondr...
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| Format: | Conference item |
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Elsevier
2018
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| _version_ | 1797063591752368128 |
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| author | Mimpen, J Carr, A Dakin, S Snelling, S |
| author_facet | Mimpen, J Carr, A Dakin, S Snelling, S |
| author_sort | Mimpen, J |
| collection | OXFORD |
| description | Interleukin-17A (IL-17) is a pro-inflammator¬y cytokine, which has been reported to be increased in the joint of patients with OA. This study aimed to identify whether IL-17 or its receptors are expressed in the joints of OA patients and establish the effect of IL-17 in vitro on primary human chondrocytes and synovial fibroblasts from the joints of OA patients. We further studied whether any anti-inflammatory agents in current clinical use were able to reduce the effects of IL-17. We hypothesize that IL-17 stimulates the production of matrix degrading and inflammatory proteins by acting on IL-17 receptors on chondrocytes and synovial fibroblasts, which can be blocked by clinically used anti-inflammatory therapeutics. |
| first_indexed | 2024-03-06T21:02:06Z |
| format | Conference item |
| id | oxford-uuid:3b395af8-ef76-4f65-bf1b-525a38e1e0c5 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:02:06Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:3b395af8-ef76-4f65-bf1b-525a38e1e0c52022-03-26T14:06:19ZInhibition of interleukin-17-induced effects in osteoarthritis - An in vitro studyConference itemhttp://purl.org/coar/resource_type/c_5794uuid:3b395af8-ef76-4f65-bf1b-525a38e1e0c5Symplectic Elements at OxfordElsevier2018Mimpen, JCarr, ADakin, SSnelling, SInterleukin-17A (IL-17) is a pro-inflammator¬y cytokine, which has been reported to be increased in the joint of patients with OA. This study aimed to identify whether IL-17 or its receptors are expressed in the joints of OA patients and establish the effect of IL-17 in vitro on primary human chondrocytes and synovial fibroblasts from the joints of OA patients. We further studied whether any anti-inflammatory agents in current clinical use were able to reduce the effects of IL-17. We hypothesize that IL-17 stimulates the production of matrix degrading and inflammatory proteins by acting on IL-17 receptors on chondrocytes and synovial fibroblasts, which can be blocked by clinically used anti-inflammatory therapeutics. |
| spellingShingle | Mimpen, J Carr, A Dakin, S Snelling, S Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study |
| title | Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study |
| title_full | Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study |
| title_fullStr | Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study |
| title_full_unstemmed | Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study |
| title_short | Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study |
| title_sort | inhibition of interleukin 17 induced effects in osteoarthritis an in vitro study |
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