Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

OBJECTIVE: Endothelial dysfunction in diabetes is characterized by decreased nitric oxide (NO) bioactivity and increased superoxide (SO) production. Reduced levels of tetrahydrobiopterin (BH4), an essential cofactor of endothelial NO synthase (eNOS), appear to be associated with eNOS enzymatic unco...

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Autori principali:	Cai, S, Khoo, J, Channon, K
Natura:	Journal article
Lingua:	English
Pubblicazione:	2005

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