Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

OBJECTIVE: Endothelial dysfunction in diabetes is characterized by decreased nitric oxide (NO) bioactivity and increased superoxide (SO) production. Reduced levels of tetrahydrobiopterin (BH4), an essential cofactor of endothelial NO synthase (eNOS), appear to be associated with eNOS enzymatic unco...

Bibliografske podrobnosti
Main Authors:	Cai, S, Khoo, J, Channon, K
Format:	Journal article
Jezik:	English
Izdano:	2005

Podobne knjige/članki

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
od: Cai, S, et al.
Izdano: (2004)

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
od: Cai, S, et al.
Izdano: (2004)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
od: Cai, S, et al.
Izdano: (2005)

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
od: Cai, S, et al.
Izdano: (2002)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
od: Channon, K
Izdano: (2004)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
od: Cai, S, et al.
Izdano: (2004)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
od: Alp, N, et al.
Izdano: (2004)

Dihydrofolate reductase is required to maintain endothelial nitric oxide synthase coupling in vivo: Insights from methotrexate-treated BH4 deficient and GTPCH overexpressing mice
od: Crabtree, M, et al.
Izdano: (2010)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
od: Alp, N, et al.
Izdano: (2004)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
od: Khoo, J, et al.
Izdano: (2005)

P683The role of nitric oxide synthase (NOS) and its essential cofactor tetrahydrobiopterin (BH4) in diabetic cardiomyopathy.
od: Duglan, D, et al.
Izdano: (2014)

The role of nitric oxide synthase (nos) and the cofactor tetrahydrobiopterin (bh4) in diabetic cardiomyopathy
od: Duglan, D
Izdano: (2016)

Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.
od: Mohan, R, et al.
Izdano: (2002)

Functional assessment of the endothelial nitric oxide synthase Glu298Asp polymorphism
od: McDonald, D, et al.
Izdano: (2002)

Tetrahydrobiopterin and nitric oxide synthase recouplers
od: Channon, KM
Izdano: (2020)

Neuronal and endothelial nitric oxide synthase gene knockout mice
od: P.L. Huang
Izdano: (1999-11-01)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
od: Crabtree, M, et al.
Izdano: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
od: Crabtree, M, et al.
Izdano: (2011)

Endothelial nitric oxide synthase and heart rate.
od: Herring, N, et al.
Izdano: (2002)

Role of nitric oxide and endothelial NO synthase in carcinogenesis
od: V. P. Deryagina, et al.
Izdano: (2021-07-01)

Targeting and translocation of endothelial nitric oxide synthase
od: T. Michel
Izdano: (1999-11-01)

Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances
od: Chiara De Luca, et al.
Izdano: (2015-01-01)

Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells.
od: McDonald, D, et al.
Izdano: (2004)

Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid
od: Santhini Ramasamy, et al.
Izdano: (1998-02-01)

Tetrahydrobiopterin Prevents Lung Ischemia/reperfusion-Induced Uncoupling of Endothelial Nitric Oxide Synthase
od: Juni, R, et al.
Izdano: (2012)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
od: Khoo, J, et al.
Izdano: (2005)

Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis.
od: Guzik, T, et al.
Izdano: (2001)

Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue
od: Andy W. C. Man, et al.
Izdano: (2022-07-01)

Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats.
od: Heaton, D, et al.
Izdano: (2007)

Evaluation of Endothelial Nitric Oxide Synthase and Nitric Oxide Levels in Preeclamptic and Normotensive Pregnant Women
od: Rajeev Gandham, et al.
Izdano: (2021-01-01)

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
od: Crabtree, M, et al.
Izdano: (2013)

High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia
od: Paul Guerby, et al.
Izdano: (2019-04-01)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
od: Khoo, J, et al.
Izdano: (2004)

Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy.
od: Channon, K, et al.
Izdano: (2000)

POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE AS PREDICTORS OF WOLFF-PARKINSON-WHITE SYNDROME
od: G. V. Matyushin, et al.
Izdano: (2017-11-01)

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
od: Ismail Sari, et al.

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
od: Ismail Sari, et al.
Izdano: (2013-01-01)

Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism in Renal Transplant Recipients
od: N Azarpira, et al.
Izdano: (2011-04-01)

Relationships between vascular/plasma biopterins and endothelial nitric oxide synthase coupling, endothelial function and inflammation, in human atherosclerosis
od: Antoniades, C, et al.
Izdano: (2008)

Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia
od: Paul Guerby, et al.
Izdano: (2021-04-01)