Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

OBJECTIVE: Endothelial dysfunction in diabetes is characterized by decreased nitric oxide (NO) bioactivity and increased superoxide (SO) production. Reduced levels of tetrahydrobiopterin (BH4), an essential cofactor of endothelial NO synthase (eNOS), appear to be associated with eNOS enzymatic unco...

Detaylı Bibliyografya
Asıl Yazarlar:	Cai, S, Khoo, J, Channon, K
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	2005

Benzer Materyaller

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
Yazar:: Cai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
Yazar:: Cai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
Yazar:: Cai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
Yazar:: Cai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
Yazar:: Channon, K
Baskı/Yayın Bilgisi: (2004)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
Yazar:: Cai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Dihydrofolate reductase is required to maintain endothelial nitric oxide synthase coupling in vivo: Insights from methotrexate-treated BH4 deficient and GTPCH overexpressing mice
Yazar:: Crabtree, M, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

P683The role of nitric oxide synthase (NOS) and its essential cofactor tetrahydrobiopterin (BH4) in diabetic cardiomyopathy.
Yazar:: Duglan, D, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

The role of nitric oxide synthase (nos) and the cofactor tetrahydrobiopterin (bh4) in diabetic cardiomyopathy
Yazar:: Duglan, D
Baskı/Yayın Bilgisi: (2016)

Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.
Yazar:: Mohan, R, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Functional assessment of the endothelial nitric oxide synthase Glu298Asp polymorphism
Yazar:: McDonald, D, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Tetrahydrobiopterin and nitric oxide synthase recouplers
Yazar:: Channon, KM
Baskı/Yayın Bilgisi: (2020)

Neuronal and endothelial nitric oxide synthase gene knockout mice
Yazar:: P.L. Huang
Baskı/Yayın Bilgisi: (1999-11-01)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
Yazar:: Crabtree, M, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
Yazar:: Crabtree, M, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Endothelial nitric oxide synthase and heart rate.
Yazar:: Herring, N, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Role of nitric oxide and endothelial NO synthase in carcinogenesis
Yazar:: V. P. Deryagina, ve diğerleri
Baskı/Yayın Bilgisi: (2021-07-01)

Targeting and translocation of endothelial nitric oxide synthase
Yazar:: T. Michel
Baskı/Yayın Bilgisi: (1999-11-01)

Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances
Yazar:: Chiara De Luca, ve diğerleri
Baskı/Yayın Bilgisi: (2015-01-01)

Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells.
Yazar:: McDonald, D, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid
Yazar:: Santhini Ramasamy, ve diğerleri
Baskı/Yayın Bilgisi: (1998-02-01)

Tetrahydrobiopterin Prevents Lung Ischemia/reperfusion-Induced Uncoupling of Endothelial Nitric Oxide Synthase
Yazar:: Juni, R, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis.
Yazar:: Guzik, T, ve diğerleri
Baskı/Yayın Bilgisi: (2001)

Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue
Yazar:: Andy W. C. Man, ve diğerleri
Baskı/Yayın Bilgisi: (2022-07-01)

Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats.
Yazar:: Heaton, D, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Evaluation of Endothelial Nitric Oxide Synthase and Nitric Oxide Levels in Preeclamptic and Normotensive Pregnant Women
Yazar:: Rajeev Gandham, ve diğerleri
Baskı/Yayın Bilgisi: (2021-01-01)

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
Yazar:: Crabtree, M, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia
Yazar:: Paul Guerby, ve diğerleri
Baskı/Yayın Bilgisi: (2019-04-01)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy.
Yazar:: Channon, K, ve diğerleri
Baskı/Yayın Bilgisi: (2000)

POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE AS PREDICTORS OF WOLFF-PARKINSON-WHITE SYNDROME
Yazar:: G. V. Matyushin, ve diğerleri
Baskı/Yayın Bilgisi: (2017-11-01)

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
Yazar:: Ismail Sari, ve diğerleri

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
Yazar:: Ismail Sari, ve diğerleri
Baskı/Yayın Bilgisi: (2013-01-01)

Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism in Renal Transplant Recipients
Yazar:: N Azarpira, ve diğerleri
Baskı/Yayın Bilgisi: (2011-04-01)

Relationships between vascular/plasma biopterins and endothelial nitric oxide synthase coupling, endothelial function and inflammation, in human atherosclerosis
Yazar:: Antoniades, C, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia
Yazar:: Paul Guerby, ve diğerleri
Baskı/Yayın Bilgisi: (2021-04-01)