Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
OBJECTIVE: Endothelial dysfunction in diabetes is characterized by decreased nitric oxide (NO) bioactivity and increased superoxide (SO) production. Reduced levels of tetrahydrobiopterin (BH4), an essential cofactor of endothelial NO synthase (eNOS), appear to be associated with eNOS enzymatic unco...
Автори: | Cai, S, Khoo, J, Channon, K |
---|---|
Формат: | Journal article |
Мова: | English |
Опубліковано: |
2005
|
Схожі ресурси
Схожі ресурси
-
Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
за авторством: Cai, S, та інші
Опубліковано: (2004) -
Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
за авторством: Cai, S, та інші
Опубліковано: (2004) -
Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
за авторством: Cai, S, та інші
Опубліковано: (2005) -
GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
за авторством: Cai, S, та інші
Опубліковано: (2002) -
Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
за авторством: Channon, K
Опубліковано: (2004)