A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation.

A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation.

The mammalian nuclear lamina protein lamin B1 is posttranslationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxyl-terminal CAAX motif. In this work, we demonstrate that the CAAX endoprotease Rce1 is required for lamin B1 endoproteolysis, demonstrate an independent...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Maske, C, Hollinshead, MS, Higbee, N, Bergo, M, Young, S, Vaux, D
Format: Journal article
Sprache:English
Veröffentlicht: 2003

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