Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.

Mutations in the human methyl-CpG-binding protein gene MECP2 cause the neurological disorder Rett syndrome and some cases of X-linked mental retardation (XLMR). We report that MeCP2 interacts with ATRX, a SWI2/SNF2 DNA helicase/ATPase that is mutated in ATRX syndrome (alpha-thalassemia/mental retard...

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Chi tiết về thư mục
Những tác giả chính:	Nan, X, Hou, J, Maclean, A, Nasir, J, Lafuente, M, Shu, X, Kriaucionis, S, Bird, A
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2007

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