Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.

Mutations in the human methyl-CpG-binding protein gene MECP2 cause the neurological disorder Rett syndrome and some cases of X-linked mental retardation (XLMR). We report that MeCP2 interacts with ATRX, a SWI2/SNF2 DNA helicase/ATPase that is mutated in ATRX syndrome (alpha-thalassemia/mental retard...

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書目詳細資料
Main Authors: Nan, X, Hou, J, Maclean, A, Nasir, J, Lafuente, M, Shu, X, Kriaucionis, S, Bird, A
格式: Journal article
語言:English
出版: 2007