HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma.
Epidemiological studies have shown that human leukocyte antigen (HLA) allelic polymorphisms are closely correlated to susceptibility to nasopharyngeal carcinoma (NPC), and in a previous study, we showed that HLA-B*46 and HLA-A*02-B*46 haplotypes were strongly associated with NPC susceptibility. In t...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer Verlag
2016
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| _version_ | 1826268018067374080 |
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| author | Wang, R Zhang, D Wu, R Hu, Y Peng, Y Chang, C Dong, T Wang, X |
| author_facet | Wang, R Zhang, D Wu, R Hu, Y Peng, Y Chang, C Dong, T Wang, X |
| author_sort | Wang, R |
| collection | OXFORD |
| description | Epidemiological studies have shown that human leukocyte antigen (HLA) allelic polymorphisms are closely correlated to susceptibility to nasopharyngeal carcinoma (NPC), and in a previous study, we showed that HLA-B*46 and HLA-A*02-B*46 haplotypes were strongly associated with NPC susceptibility. In this retrospective study, we investigated the phenotype of the HLA-A and HLA-B alleles and haplotypes and correlated these data to the clinical and pathological parameters of NPC to understand the role of HLA alleles and haplotypes in NPC prognosis. The cohort comprised 117 NPC patients from a Han population in Xinjiang. The local recurrence-free survival (LRFS), distant metastasis- free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed. The 5-year DMFS of the HLA-A*02-B*46 haplotype carriers and non-carriers was 66.4% and 90.3%, respectively. In addition, age was found to be a prognostic factor for LRFS, DFS, and OS (P=0.032, 0.040, and 0.013, respectively). We found that the HLA-A*02-B*46 haplotype might be a prognostic marker in addition to the traditional TNM staging in patients with NPC. |
| first_indexed | 2024-03-06T21:03:09Z |
| format | Journal article |
| id | oxford-uuid:3b8dd661-caf9-4ee6-9219-876e605345a3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:03:09Z |
| publishDate | 2016 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | oxford-uuid:3b8dd661-caf9-4ee6-9219-876e605345a32022-03-26T14:08:18ZHLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3b8dd661-caf9-4ee6-9219-876e605345a3EnglishSymplectic Elements at OxfordSpringer Verlag2016Wang, RZhang, DWu, RHu, YPeng, YChang, CDong, TWang, XEpidemiological studies have shown that human leukocyte antigen (HLA) allelic polymorphisms are closely correlated to susceptibility to nasopharyngeal carcinoma (NPC), and in a previous study, we showed that HLA-B*46 and HLA-A*02-B*46 haplotypes were strongly associated with NPC susceptibility. In this retrospective study, we investigated the phenotype of the HLA-A and HLA-B alleles and haplotypes and correlated these data to the clinical and pathological parameters of NPC to understand the role of HLA alleles and haplotypes in NPC prognosis. The cohort comprised 117 NPC patients from a Han population in Xinjiang. The local recurrence-free survival (LRFS), distant metastasis- free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed. The 5-year DMFS of the HLA-A*02-B*46 haplotype carriers and non-carriers was 66.4% and 90.3%, respectively. In addition, age was found to be a prognostic factor for LRFS, DFS, and OS (P=0.032, 0.040, and 0.013, respectively). We found that the HLA-A*02-B*46 haplotype might be a prognostic marker in addition to the traditional TNM staging in patients with NPC. |
| spellingShingle | Wang, R Zhang, D Wu, R Hu, Y Peng, Y Chang, C Dong, T Wang, X HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma. |
| title | HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma. |
| title_full | HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma. |
| title_fullStr | HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma. |
| title_full_unstemmed | HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma. |
| title_short | HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma. |
| title_sort | hla a 02 b 46 haplotype an adverse prognostic factor in han patients with nasopharyngeal carcinoma |
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