Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina
Two-pore domain (K2P) potassium channels perform essential roles in neuronal function. These channels produce background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability. 15 different K2P channels have been identified in mammals and the...
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| Format: | Journal article |
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Nature Publishing Group
2017
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| _version_ | 1826268039541161984 |
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| author | Hughes, S Foster, R Peirson, S Hankins, M |
| author_facet | Hughes, S Foster, R Peirson, S Hankins, M |
| author_sort | Hughes, S |
| collection | OXFORD |
| description | Two-pore domain (K2P) potassium channels perform essential roles in neuronal function. These channels produce background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability. 15 different K2P channels have been identified in mammals and these channels perform important roles in a wide number of physiological systems. However, to date there is only limited data available concerning the expression and role of K2P channels in the retina. In this study we conduct the first comprehensive study of K2P channel expression in the retina. Our data show that K2P channels are widely expressed in the mouse retina, with variations in expression detected at different times of day and throughout postnatal development. The highest levels of K2P channel expression are observed for Müller cells (TWIK-1, TASK-3, TRAAK, and TREK-2) and retinal ganglion cells (TASK-1, TREK-1, TWIK-1, TWIK-2 and TWIK-3). These data offer new insight into the channels that regulate the resting membrane potential and electrical activity of retinal cells, and suggests that K2P channels are well placed to act as central regulators of visual signalling pathways. The prominent role of K2P channels in neuroprotection offers novel avenues of research into the treatment of common retinal diseases. |
| first_indexed | 2024-03-06T21:03:30Z |
| format | Journal article |
| id | oxford-uuid:3baa342c-24e2-4116-be31-4cadca062958 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:03:30Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:3baa342c-24e2-4116-be31-4cadca0629582022-03-26T14:08:56ZExpression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retinaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3baa342c-24e2-4116-be31-4cadca062958Symplectic Elements at OxfordNature Publishing Group2017Hughes, SFoster, RPeirson, SHankins, MTwo-pore domain (K2P) potassium channels perform essential roles in neuronal function. These channels produce background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability. 15 different K2P channels have been identified in mammals and these channels perform important roles in a wide number of physiological systems. However, to date there is only limited data available concerning the expression and role of K2P channels in the retina. In this study we conduct the first comprehensive study of K2P channel expression in the retina. Our data show that K2P channels are widely expressed in the mouse retina, with variations in expression detected at different times of day and throughout postnatal development. The highest levels of K2P channel expression are observed for Müller cells (TWIK-1, TASK-3, TRAAK, and TREK-2) and retinal ganglion cells (TASK-1, TREK-1, TWIK-1, TWIK-2 and TWIK-3). These data offer new insight into the channels that regulate the resting membrane potential and electrical activity of retinal cells, and suggests that K2P channels are well placed to act as central regulators of visual signalling pathways. The prominent role of K2P channels in neuroprotection offers novel avenues of research into the treatment of common retinal diseases. |
| spellingShingle | Hughes, S Foster, R Peirson, S Hankins, M Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina |
| title | Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina |
| title_full | Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina |
| title_fullStr | Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina |
| title_full_unstemmed | Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina |
| title_short | Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina |
| title_sort | expression and localisation of two pore domain k2p background leak potassium ion channels in the mouse retina |
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