Structure unifies the viral universe.
Is it possible to meaningfully comprehend the diversity of the viral world? We propose that it is. This is based on the observation that, although there is immense genomic variation, every infective virion is restricted by strict constraints in structure space (i.e., there are a limited number of wa...
| Main Authors: | , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2012
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| _version_ | 1826268042217127936 |
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| author | Abrescia, N Bamford, D Grimes, J Stuart, D |
| author_facet | Abrescia, N Bamford, D Grimes, J Stuart, D |
| author_sort | Abrescia, N |
| collection | OXFORD |
| description | Is it possible to meaningfully comprehend the diversity of the viral world? We propose that it is. This is based on the observation that, although there is immense genomic variation, every infective virion is restricted by strict constraints in structure space (i.e., there are a limited number of ways to fold a protein chain, and only a small subset of these have the potential to construct a virion, the hallmark of a virus). We have previously suggested the use of structure for the higher-order classification of viruses, where genomic similarities are no longer observable. Here, we summarize the arguments behind this proposal, describe the current status of structural work, highlighting its power to infer common ancestry, and discuss the limitations and obstacles ahead of us. We also reflect on the future opportunities for a more concerted effort to provide high-throughput methods to facilitate the large-scale sampling of the virosphere. |
| first_indexed | 2024-03-06T21:03:32Z |
| format | Journal article |
| id | oxford-uuid:3baee5e4-2e28-40d3-86b7-4bbf6f8cea10 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:03:32Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:3baee5e4-2e28-40d3-86b7-4bbf6f8cea102022-03-26T14:09:03ZStructure unifies the viral universe.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3baee5e4-2e28-40d3-86b7-4bbf6f8cea10EnglishSymplectic Elements at Oxford2012Abrescia, NBamford, DGrimes, JStuart, DIs it possible to meaningfully comprehend the diversity of the viral world? We propose that it is. This is based on the observation that, although there is immense genomic variation, every infective virion is restricted by strict constraints in structure space (i.e., there are a limited number of ways to fold a protein chain, and only a small subset of these have the potential to construct a virion, the hallmark of a virus). We have previously suggested the use of structure for the higher-order classification of viruses, where genomic similarities are no longer observable. Here, we summarize the arguments behind this proposal, describe the current status of structural work, highlighting its power to infer common ancestry, and discuss the limitations and obstacles ahead of us. We also reflect on the future opportunities for a more concerted effort to provide high-throughput methods to facilitate the large-scale sampling of the virosphere. |
| spellingShingle | Abrescia, N Bamford, D Grimes, J Stuart, D Structure unifies the viral universe. |
| title | Structure unifies the viral universe. |
| title_full | Structure unifies the viral universe. |
| title_fullStr | Structure unifies the viral universe. |
| title_full_unstemmed | Structure unifies the viral universe. |
| title_short | Structure unifies the viral universe. |
| title_sort | structure unifies the viral universe |
| work_keys_str_mv | AT abrescian structureunifiestheviraluniverse AT bamfordd structureunifiestheviraluniverse AT grimesj structureunifiestheviraluniverse AT stuartd structureunifiestheviraluniverse |