CD161-expressing human T cells.
Expression of the Natural Killer cell receptor CD161 has recently been identified on a subset of T cells, including both CD4+ T helper and CD8+ T cells. Expression of this molecule within the adult circulation is restricted to those T cells with a memory phenotype. However, the distinct properties o...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797063695611723776 |
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| author | Fergusson, JR Fleming, V Klenerman, P |
| author_facet | Fergusson, JR Fleming, V Klenerman, P |
| author_sort | Fergusson, JR |
| collection | OXFORD |
| description | Expression of the Natural Killer cell receptor CD161 has recently been identified on a subset of T cells, including both CD4+ T helper and CD8+ T cells. Expression of this molecule within the adult circulation is restricted to those T cells with a memory phenotype. However, the distinct properties of these T cell populations is yet to be fully determined, although expression of CD161 has been related to the secretion of interleukin-17, and therefore to a type 17 phenotype. Recent studies have aimed to determine both the origin of these cells and the significance of CD161 expression as either a marker of specific cell types or as an effector and regulator of lymphocyte function, and hence to characterize the role of these CD161+ cells within a variety of human diseases in which they have been implicated. |
| first_indexed | 2024-03-06T21:03:35Z |
| format | Journal article |
| id | oxford-uuid:3bb3aba5-6a6e-4fd5-9c7a-c2b18f47b1e2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:03:35Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:3bb3aba5-6a6e-4fd5-9c7a-c2b18f47b1e22022-03-26T14:09:09ZCD161-expressing human T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3bb3aba5-6a6e-4fd5-9c7a-c2b18f47b1e2EnglishSymplectic Elements at Oxford2011Fergusson, JRFleming, VKlenerman, PExpression of the Natural Killer cell receptor CD161 has recently been identified on a subset of T cells, including both CD4+ T helper and CD8+ T cells. Expression of this molecule within the adult circulation is restricted to those T cells with a memory phenotype. However, the distinct properties of these T cell populations is yet to be fully determined, although expression of CD161 has been related to the secretion of interleukin-17, and therefore to a type 17 phenotype. Recent studies have aimed to determine both the origin of these cells and the significance of CD161 expression as either a marker of specific cell types or as an effector and regulator of lymphocyte function, and hence to characterize the role of these CD161+ cells within a variety of human diseases in which they have been implicated. |
| spellingShingle | Fergusson, JR Fleming, V Klenerman, P CD161-expressing human T cells. |
| title | CD161-expressing human T cells. |
| title_full | CD161-expressing human T cells. |
| title_fullStr | CD161-expressing human T cells. |
| title_full_unstemmed | CD161-expressing human T cells. |
| title_short | CD161-expressing human T cells. |
| title_sort | cd161 expressing human t cells |
| work_keys_str_mv | AT fergussonjr cd161expressinghumantcells AT flemingv cd161expressinghumantcells AT klenermanp cd161expressinghumantcells |