Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers.
BACKGROUND: The role of FOXP1 in sporadic breast cancers has been widely studied but its role in familial breast cancers is yet unexplored. AIMS: To investigate FOXP1 expression in different molecular subtypes of familial breast cancers and to correlate its expression with clinicopathological param...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2009
|
| _version_ | 1797063699220922368 |
|---|---|
| author | Rayoo, M Yan, M Takano, E Bates, G Brown, P Banham, A Fox, S |
| author_facet | Rayoo, M Yan, M Takano, E Bates, G Brown, P Banham, A Fox, S |
| author_sort | Rayoo, M |
| collection | OXFORD |
| description | BACKGROUND: The role of FOXP1 in sporadic breast cancers has been widely studied but its role in familial breast cancers is yet unexplored. AIMS: To investigate FOXP1 expression in different molecular subtypes of familial breast cancers and to correlate its expression with clinicopathological parameters, oestrogen receptors (ER) and survival. METHODS: Immunohistochemical staining for FOXP1 was performed in 126 familial breast carcinomas comprising 35 BRCA1, 34 BRCA2 and 57 BRCAX. RESULTS: Nuclear FOXP1 expression ranged from focal weak to widespread strong expression. Expression of FOXP1 was higher in familial breast cancers (54%) compared with sporadic cancers (46%) (p<0.001). There was a significant correlation between FOXP1 with ERalpha (p = 0.038) and ERbeta (p = 0.007) in familial breast cancers. FOXP1 was more highly expressed in familial breast cancers compared with sporadic cancers for luminal (p = 0.021) and basal (p<0.001), but not HER2 and null phenotypes (both p>0.05). The absence of FOXP1 expression was associated with a shorter relapse-free (p = 0.025) and overall survival (p = 0.009) in familial breast cancer. Negativity for FOXP1 was associated with a significantly worse overall survival in BRCA2 cancers (p = 0.021) and there was a non-significant separation of the survival curves for BRCA1 cancers (p = 0.183). No differences in survival were seen for BRCAX cancers (p = 0.762). CONCLUSION: Results suggest that FOXP1 demonstrates different expression patterns in familial breast cancers than sporadic tumours, even in tumours showing similar phenotypes. They also suggest a different role of FOXP1 as a tumour suppressor in familial tumours, which is unrelated to ER expression and may impact on therapeutic options. |
| first_indexed | 2024-03-06T21:03:39Z |
| format | Journal article |
| id | oxford-uuid:3bb85436-8933-4743-b0ba-2ef7f21429be |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:03:39Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:3bb85436-8933-4743-b0ba-2ef7f21429be2022-03-26T14:09:14ZExpression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3bb85436-8933-4743-b0ba-2ef7f21429beEnglishSymplectic Elements at Oxford2009Rayoo, MYan, MTakano, EBates, GBrown, PBanham, AFox, S BACKGROUND: The role of FOXP1 in sporadic breast cancers has been widely studied but its role in familial breast cancers is yet unexplored. AIMS: To investigate FOXP1 expression in different molecular subtypes of familial breast cancers and to correlate its expression with clinicopathological parameters, oestrogen receptors (ER) and survival. METHODS: Immunohistochemical staining for FOXP1 was performed in 126 familial breast carcinomas comprising 35 BRCA1, 34 BRCA2 and 57 BRCAX. RESULTS: Nuclear FOXP1 expression ranged from focal weak to widespread strong expression. Expression of FOXP1 was higher in familial breast cancers (54%) compared with sporadic cancers (46%) (p<0.001). There was a significant correlation between FOXP1 with ERalpha (p = 0.038) and ERbeta (p = 0.007) in familial breast cancers. FOXP1 was more highly expressed in familial breast cancers compared with sporadic cancers for luminal (p = 0.021) and basal (p<0.001), but not HER2 and null phenotypes (both p>0.05). The absence of FOXP1 expression was associated with a shorter relapse-free (p = 0.025) and overall survival (p = 0.009) in familial breast cancer. Negativity for FOXP1 was associated with a significantly worse overall survival in BRCA2 cancers (p = 0.021) and there was a non-significant separation of the survival curves for BRCA1 cancers (p = 0.183). No differences in survival were seen for BRCAX cancers (p = 0.762). CONCLUSION: Results suggest that FOXP1 demonstrates different expression patterns in familial breast cancers than sporadic tumours, even in tumours showing similar phenotypes. They also suggest a different role of FOXP1 as a tumour suppressor in familial tumours, which is unrelated to ER expression and may impact on therapeutic options. |
| spellingShingle | Rayoo, M Yan, M Takano, E Bates, G Brown, P Banham, A Fox, S Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers. |
| title | Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers. |
| title_full | Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers. |
| title_fullStr | Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers. |
| title_full_unstemmed | Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers. |
| title_short | Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers. |
| title_sort | expression of the forkhead box transcription factor foxp1 is associated with oestrogen receptor alpha oestrogen receptor beta and improved survival in familial breast cancers |
| work_keys_str_mv | AT rayoom expressionoftheforkheadboxtranscriptionfactorfoxp1isassociatedwithoestrogenreceptoralphaoestrogenreceptorbetaandimprovedsurvivalinfamilialbreastcancers AT yanm expressionoftheforkheadboxtranscriptionfactorfoxp1isassociatedwithoestrogenreceptoralphaoestrogenreceptorbetaandimprovedsurvivalinfamilialbreastcancers AT takanoe expressionoftheforkheadboxtranscriptionfactorfoxp1isassociatedwithoestrogenreceptoralphaoestrogenreceptorbetaandimprovedsurvivalinfamilialbreastcancers AT batesg expressionoftheforkheadboxtranscriptionfactorfoxp1isassociatedwithoestrogenreceptoralphaoestrogenreceptorbetaandimprovedsurvivalinfamilialbreastcancers AT brownp expressionoftheforkheadboxtranscriptionfactorfoxp1isassociatedwithoestrogenreceptoralphaoestrogenreceptorbetaandimprovedsurvivalinfamilialbreastcancers AT banhama expressionoftheforkheadboxtranscriptionfactorfoxp1isassociatedwithoestrogenreceptoralphaoestrogenreceptorbetaandimprovedsurvivalinfamilialbreastcancers AT foxs expressionoftheforkheadboxtranscriptionfactorfoxp1isassociatedwithoestrogenreceptoralphaoestrogenreceptorbetaandimprovedsurvivalinfamilialbreastcancers |