Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein

Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein

The activation of at least 23 different mammalian kinases requires the phosphorylation of their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide-binding PH domain to the catalytic domain, which contains a docking site for substrates called the PIF pocket. Here, we used a...

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Bibliographic Details
Main Authors: Sacerdoti, M, Gross, LSF, Riley, A, Zehnder, K, Ghode, A, Klinke, S, Anand, GS, Paris, K, Winkel, A, Herbrand, A, Godage, HY, Cozier, GE, Süß, E, Schulze, JO, Pastor-Flores, D, Bollini, M, Cappellari, MV, Svergun, D, Gräwert, MA, Aramendia, PF, Leroux, AE, Potter, B, Camacho, CJ, Biondi, RM
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2023

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