The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.
BACKGROUND: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively weak inhibitor of the enzyme for P. carinii. Deter...
Main Authors: | Champness, J, Achari, A, Ballantine, S, Bryant, P, Delves, C, Stammers, D |
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格式: | Journal article |
语言: | English |
出版: |
1994
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