The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.

Show other versions (1)

BACKGROUND: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively weak inhibitor of the enzyme for P. carinii. Deter...

书目详细资料
Main Authors:	Champness, J, Achari, A, Ballantine, S, Bryant, P, Delves, C, Stammers, D
格式:	Journal article
语言:	English
出版:	1994

相似书籍

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.
由: Champness, J, et al.
出版: (1994)

Preliminary crystallographic data for Pneumocystis carinii dihydrofolate reductase.
由: Stammers, D, et al.
出版: (1993)

Refolding of recombinant Pneumocystis carinii dihydrofolate reductase and characterization of the enzyme.
由: Delves, C, et al.
出版: (1993)

The binding of trimethoprim to bacterial dihydrofolate reductase.
由: Baker, D, et al.
出版: (1981)

Pneumocystis carinii
由: J. M. HOPKIN
出版: (1993-02-01)

Pneumocystis carinii
由: J.M. HOPKIN
出版: (1993-02-01)

Crystallographic investigation of the cooperative interaction between trimethoprim, reduced cofactor and dihydrofolate reductase.
由: Champness, J, et al.
出版: (1986)

The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase.
由: Volpe, F, et al.
出版: (1992)

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.
由: Stammers, D, et al.
出版: (1987)

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.
由: Matthews, D, et al.
出版: (1985)

Pneumocystis carinii pneumonia with pleurisy, platypnoea and orthodeoxia.
由: Newton, P, et al.
出版: (2003)

Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
由: Michael J. Linke, et al.
出版: (2003-12-01)

Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate.
由: Francois D Rouleau, et al.
出版: (2024-04-01)

Infection with Pneumocystis carinii is prevalent in healthy Gambian children.
由: Wakefield, A, et al.
出版: (1990)

Pneumocystis carinii Pneumonia in HIV — Investigate or Just Treat?
由: Steven Kesten
出版: (1994-01-01)

Basic biology of Pneumocystis carinii: a mini review
由: Wanderley de Souza, et al.
出版: (2005-12-01)

Pneumocystis carinii versus Pneumocystis jiroveci: Another Misnomer (Response to Stringer et al.)
由: Walter T. Hughes
出版: (2003-02-01)

HIV in pregnancy: a case of Pneumocystis (carinii) jiroveci pneumonia.
由: Parisaei, M, et al.
出版: (2010)

Pneumocystis carinii: A Review of an Important Opportunistic Pathogen in AIDS
由: M John Gill, et al.
出版: (1991-01-01)

Pneumocystis carinii: its incidence in rodents and enhancement of the infection by corticosteroids
由: Helly A. Lage, et al.
出版: (1973-01-01)

Ploidy of cell-sorted trophic and cystic forms of Pneumocystis carinii.
由: Anna Martinez, et al.
出版: (2011-01-01)

Risk Factors for Breakthrough Pneumocystis carinii Pneumonia on Aerosol Pentamidine Prophylaxis
由: RA McIvor, et al.
出版: (1995-01-01)

Intestinal cryptosporidiosis. association with Pneumocystis carinii, cytomegalovirus and Candida sp. Infections
由: K. I. R. Coelho, et al.
出版: (1987-10-01)

Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
由: Aimable Nahimana, et al.
出版: (2003-07-01)

Adaptations for Pressure and Temperature in Dihydrofolate Reductases
由: Ryan W. Penhallurick, et al.
出版: (2021-08-01)

Diagnosis and Treatment of Pneumocystis Carinii Pneumonia (PCP)/ Pneumocystis Jirovecii Pneumonia in HIV patient: A Case Report
由: Dewi Rizki Agustina, et al.
出版: (2017-12-01)

Clinical Pharmacist Involved in the Treatment of Pneumocystis carinii Pneumonia: A Case Report
由: Lai F, et al.
出版: (2024-11-01)

Infección pulmonar por pneumocystis carinii: microorganismo, anatomía patológica y diagnóstico
由: David Oddo Benavides
出版: (2017-03-01)

Growth and airborne transmission of cell-sorted life cycle stages of Pneumocystis carinii.
由: Anna Martinez, et al.
出版: (2013-01-01)

Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients Micofenolato mofetil pode proteger contra a pneumonia por Pneumocystis carinii em transplantados renais
由: Luiz Sergio Azevedo, et al.
出版: (2005-06-01)

Dihydrofolate reductase and biopterin recycling in cardiovascular disease.
由: Crabtree, M, et al.
出版: (2009)

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.
由: Kuyper, L, et al.
出版: (1985)

AIDS-Related Extrapulmonary Pneumocystis carinii Infection Presenting as a Solitary Rectal Ulcer
由: Eric M Yoshida, et al.
出版: (1996-01-01)

Risk for Pneumocystis carinii Transmission among Patients with Pneumonia: a Molecular Epidemiology Study
由: Elodie Senggen Manoloff, et al.
出版: (2003-01-01)

O papel do LBA na identificação de Pneumonia a Pneumocystis carinii
由: C. Pardal, et al.
出版: (2000-05-01)

Genetic Variation in Pneumocystis carinii Isolates from Different Geographic Regions: Implications for Transmission
由: Charles B. Beard, et al.
出版: (2000-06-01)

Pneumocystis carinii pneumonia, pulmonary tuberculosis and visceral leishmaniasis in an adult HIV negative patient
由: Antonio Carlos Toledo Jr., et al.

Alteration in expression of the rat mitochondrial ATPase 6 gene during <it>Pneumocystis carinii</it> infection
由: Bartlett Marilyn S, et al.
出版: (2001-06-01)

Microarray studies on effects of <it>Pneumocystis carinii </it>infection on global gene expression in alveolar macrophages
由: Liao Chung-Ping, et al.
出版: (2010-04-01)

Aerosolised pentamidine for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome Aerosol de pentamidina no tratamento da pneumonia por Pneumocystis carinii em pacientes com a síndrome da imunodeficiência adquirida
由: Adriana Weinberg, et al.
出版: (1990-08-01)