The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.

Показать другие версии (1)

BACKGROUND: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively weak inhibitor of the enzyme for P. carinii. Deter...

Полное описание

Библиографические подробности
Главные авторы:	Champness, J, Achari, A, Ballantine, S, Bryant, P, Delves, C, Stammers, D
Формат:	Journal article
Язык:	English
Опубликовано:	1994

Схожие документы

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.
по: Champness, J, и др.
Опубликовано: (1994)

Preliminary crystallographic data for Pneumocystis carinii dihydrofolate reductase.
по: Stammers, D, и др.
Опубликовано: (1993)

Refolding of recombinant Pneumocystis carinii dihydrofolate reductase and characterization of the enzyme.
по: Delves, C, и др.
Опубликовано: (1993)

The binding of trimethoprim to bacterial dihydrofolate reductase.
по: Baker, D, и др.
Опубликовано: (1981)

Synthesis of 2,4-Diaminopteridines with Bulky Lipophilic Groups at the 6-Position as Inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mammalian Dihydrofolate Reductase
по: Rosowsky Andre, и др.
Опубликовано: (1997-09-01)

Pneumocystis carinii
по: J. M. HOPKIN
Опубликовано: (1993-02-01)

Pneumocystis carinii
по: J.M. HOPKIN
Опубликовано: (1993-02-01)

Crystallographic investigation of the cooperative interaction between trimethoprim, reduced cofactor and dihydrofolate reductase.
по: Champness, J, и др.
Опубликовано: (1986)

The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase.
по: Volpe, F, и др.
Опубликовано: (1992)

Pneumocystis carinii Pneumonia (PCP)
по: Praijitr Tanan
Опубликовано: (2015-02-01)

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.
по: Stammers, D, и др.
Опубликовано: (1987)

Comprehensive and definitive structural identities of Pneumocystis carinii sterols
по: José-Luis Giner, и др.
Опубликовано: (2002-07-01)

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.
по: Matthews, D, и др.
Опубликовано: (1985)

Pneumocystis carinii pneumonia with pleurisy, platypnoea and orthodeoxia.
по: Newton, P, и др.
Опубликовано: (2003)

Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
по: Michael J. Linke, и др.
Опубликовано: (2003-12-01)

Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate.
по: Francois D Rouleau, и др.
Опубликовано: (2024-04-01)

Infection with Pneumocystis carinii is prevalent in healthy Gambian children.
по: Wakefield, A, и др.
Опубликовано: (1990)

Pneumocystis carinii Pneumonia in HIV — Investigate or Just Treat?
по: Steven Kesten
Опубликовано: (1994-01-01)

Basic biology of Pneumocystis carinii: a mini review
по: Wanderley de Souza, и др.
Опубликовано: (2005-12-01)

Pneumocystis carinii pneumonia in a hiv-positive patient
по: A.H.M van Heese, и др.
Опубликовано: (2010-03-01)

Immunization with Pneumocystis carinii A121–85 antigen activates immune function against P. carinii
по: Tong Tong, и др.
Опубликовано: (2021-06-01)

Pneumocystis carinii versus Pneumocystis jiroveci: Another Misnomer (Response to Stringer et al.)
по: Walter T. Hughes
Опубликовано: (2003-02-01)

HIV in pregnancy: a case of Pneumocystis (carinii) jiroveci pneumonia.
по: Parisaei, M, и др.
Опубликовано: (2010)

Pneumocystis carinii: A Review of an Important Opportunistic Pathogen in AIDS
по: M John Gill, и др.
Опубликовано: (1991-01-01)

Pneumocystis carinii: its incidence in rodents and enhancement of the infection by corticosteroids
по: Helly A. Lage, и др.
Опубликовано: (1973-01-01)

Ploidy of cell-sorted trophic and cystic forms of Pneumocystis carinii.
по: Anna Martinez, и др.
Опубликовано: (2011-01-01)

SU UN CASO DI POLMONITE DA PNEUMOCYSTIS CARINII
по: V. Fabbrizi, и др.
Опубликовано: (2005-09-01)

Risk Factors for Breakthrough Pneumocystis carinii Pneumonia on Aerosol Pentamidine Prophylaxis
по: RA McIvor, и др.
Опубликовано: (1995-01-01)

Intestinal cryptosporidiosis. association with Pneumocystis carinii, cytomegalovirus and Candida sp. Infections
по: K. I. R. Coelho, и др.
Опубликовано: (1987-10-01)

Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
по: Aimable Nahimana, и др.
Опубликовано: (2003-07-01)

Adaptations for Pressure and Temperature in Dihydrofolate Reductases
по: Ryan W. Penhallurick, и др.
Опубликовано: (2021-08-01)

Diagnosis and Treatment of Pneumocystis Carinii Pneumonia (PCP)/ Pneumocystis Jirovecii Pneumonia in HIV patient: A Case Report
по: Dewi Rizki Agustina, и др.
Опубликовано: (2017-12-01)

Clinical Pharmacist Involved in the Treatment of Pneumocystis carinii Pneumonia: A Case Report
по: Lai F, и др.
Опубликовано: (2024-11-01)

Infección pulmonar por pneumocystis carinii: microorganismo, anatomía patológica y diagnóstico
по: David Oddo Benavides
Опубликовано: (2017-03-01)

Growth and airborne transmission of cell-sorted life cycle stages of Pneumocystis carinii.
по: Anna Martinez, и др.
Опубликовано: (2013-01-01)

Characterizations of Pneumocystis carinii and rat lung lipids: glyceryl ethers and fatty alcohols
по: Edna S. Kaneshiro, и др.
Опубликовано: (1998-10-01)

Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients Micofenolato mofetil pode proteger contra a pneumonia por Pneumocystis carinii em transplantados renais
по: Luiz Sergio Azevedo, и др.
Опубликовано: (2005-06-01)

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.
по: Kuyper, L, и др.
Опубликовано: (1985)

Dihydrofolate reductase and biopterin recycling in cardiovascular disease.
по: Crabtree, M, и др.
Опубликовано: (2009)

AIDS-Related Extrapulmonary Pneumocystis carinii Infection Presenting as a Solitary Rectal Ulcer
по: Eric M Yoshida, и др.
Опубликовано: (1996-01-01)