N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse.
Herpes simplex virus encephalitis (HSVE) is a devastating condition that relapses, often with a chorea in children, despite adequate antiviral treatment. At relapse, evidence of viral replication is frequently absent, suggesting that the relapse may be immune-mediated. Seven children who had a neuro...
| Päätekijät: | , , , , , , , , , , |
|---|---|
| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
2014
|
| _version_ | 1826268093491445760 |
|---|---|
| author | Hacohen, Y Deiva, K Pettingill, P Waters, P Siddiqui, A Chretien, P Menson, E Lin, J Tardieu, M Vincent, A Lim, M |
| author_facet | Hacohen, Y Deiva, K Pettingill, P Waters, P Siddiqui, A Chretien, P Menson, E Lin, J Tardieu, M Vincent, A Lim, M |
| author_sort | Hacohen, Y |
| collection | OXFORD |
| description | Herpes simplex virus encephalitis (HSVE) is a devastating condition that relapses, often with a chorea in children, despite adequate antiviral treatment. At relapse, evidence of viral replication is frequently absent, suggesting that the relapse may be immune-mediated. Seven children who had a neurological relapse following their initial encephalitis, identified from 20 cases of pediatric HSVE, were studied. Serum and/or cerebrospinal fluid (CSF) were tested for N-methyl-D-aspartate receptor (NMDAR) and other antibodies previously reported in central nervous system autoimmunity. Five of the 7 relapsing children had choreoathetosis; 2 of these were NMDAR antibody-positive, 2 were negative (1 with HSV-positive CSF), and 1 was not available for testing. An additional patient, who relapsed with cognitive regression but with no movement disorder, was also NMDAR antibody-positive. In 2 of the NMDAR antibody-positive patients who were treated at relapse and in 1 who was treated only after 10 years of having a relapsing encephalopathy, a beneficial response was observed. Neurological relapses after HSVE may frequently be immune-mediated, particularly in children with chorea. NMDAR antibodies are common, and immunotherapy may be beneficial. |
| first_indexed | 2024-03-06T21:04:18Z |
| format | Journal article |
| id | oxford-uuid:3beef6c4-ca6f-43d2-a63b-bb0c1a7db42e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:04:18Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:3beef6c4-ca6f-43d2-a63b-bb0c1a7db42e2022-03-26T14:10:31ZN-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3beef6c4-ca6f-43d2-a63b-bb0c1a7db42eEnglishSymplectic Elements at Oxford2014Hacohen, YDeiva, KPettingill, PWaters, PSiddiqui, AChretien, PMenson, ELin, JTardieu, MVincent, ALim, MHerpes simplex virus encephalitis (HSVE) is a devastating condition that relapses, often with a chorea in children, despite adequate antiviral treatment. At relapse, evidence of viral replication is frequently absent, suggesting that the relapse may be immune-mediated. Seven children who had a neurological relapse following their initial encephalitis, identified from 20 cases of pediatric HSVE, were studied. Serum and/or cerebrospinal fluid (CSF) were tested for N-methyl-D-aspartate receptor (NMDAR) and other antibodies previously reported in central nervous system autoimmunity. Five of the 7 relapsing children had choreoathetosis; 2 of these were NMDAR antibody-positive, 2 were negative (1 with HSV-positive CSF), and 1 was not available for testing. An additional patient, who relapsed with cognitive regression but with no movement disorder, was also NMDAR antibody-positive. In 2 of the NMDAR antibody-positive patients who were treated at relapse and in 1 who was treated only after 10 years of having a relapsing encephalopathy, a beneficial response was observed. Neurological relapses after HSVE may frequently be immune-mediated, particularly in children with chorea. NMDAR antibodies are common, and immunotherapy may be beneficial. |
| spellingShingle | Hacohen, Y Deiva, K Pettingill, P Waters, P Siddiqui, A Chretien, P Menson, E Lin, J Tardieu, M Vincent, A Lim, M N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. |
| title | N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. |
| title_full | N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. |
| title_fullStr | N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. |
| title_full_unstemmed | N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. |
| title_short | N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. |
| title_sort | n methyl d aspartate receptor antibodies in post herpes simplex virus encephalitis neurological relapse |
| work_keys_str_mv | AT hacoheny nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT deivak nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT pettingillp nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT watersp nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT siddiquia nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT chretienp nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT mensone nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT linj nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT tardieum nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT vincenta nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse AT limm nmethyldaspartatereceptorantibodiesinpostherpessimplexvirusencephalitisneurologicalrelapse |