Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data.
OBJECTIVE: The goal was to determine the predictors of a prolonged course for children with acute otitis media. METHODS: A meta-analysis of data with the observation groups of 6 randomized, controlled trials was performed. Participants were 824 children, 6 months to 12 years of age, with acute otit...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1797063749575639040 |
|---|---|
| author | Rovers, M Glasziou, P Appelman, C Burke, P McCormick, D Damoiseaux, R Little, P Le Saux, N Hoes, A |
| author_facet | Rovers, M Glasziou, P Appelman, C Burke, P McCormick, D Damoiseaux, R Little, P Le Saux, N Hoes, A |
| author_sort | Rovers, M |
| collection | OXFORD |
| description | OBJECTIVE: The goal was to determine the predictors of a prolonged course for children with acute otitis media. METHODS: A meta-analysis of data with the observation groups of 6 randomized, controlled trials was performed. Participants were 824 children, 6 months to 12 years of age, with acute otitis media. The primary outcome was a prolonged course of acute otitis media, which was defined as fever and/or pain at 3 to 7 days. RESULTS: Of the 824 included children, 303 had pain and/or fever at 3 to 7 days. Independent predictors of a prolonged course were age of < 2 years and bilateral acute otitis media. The absolute risk of pain and/or fever at 3 to 7 days for children < 2 years of age with bilateral acute otitis media (20% of all children) was 55%, and that for children > or = 2 years of age with unilateral acute otitis media (47% of all children) was 25%. CONCLUSIONS: The risk of a prolonged course was 2 times higher for children < 2 years of age with bilateral acute otitis media than for children > or = 2 years of age with unilateral acute otitis media. Clinicians can use these features (ie, age of < 2 years and bilateral acute otitis media) to inform parents more explicitly about the expected course of their child's otitis media and to explain which features should prompt parents to contact their clinician for reexamination of the child. |
| first_indexed | 2024-03-06T21:04:22Z |
| format | Journal article |
| id | oxford-uuid:3bf2e14b-6abf-479b-a15e-2c6b27ae475d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:04:22Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:3bf2e14b-6abf-479b-a15e-2c6b27ae475d2022-03-26T14:10:38ZPredictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3bf2e14b-6abf-479b-a15e-2c6b27ae475dEnglishSymplectic Elements at Oxford2007Rovers, MGlasziou, PAppelman, CBurke, PMcCormick, DDamoiseaux, RLittle, PLe Saux, NHoes, A OBJECTIVE: The goal was to determine the predictors of a prolonged course for children with acute otitis media. METHODS: A meta-analysis of data with the observation groups of 6 randomized, controlled trials was performed. Participants were 824 children, 6 months to 12 years of age, with acute otitis media. The primary outcome was a prolonged course of acute otitis media, which was defined as fever and/or pain at 3 to 7 days. RESULTS: Of the 824 included children, 303 had pain and/or fever at 3 to 7 days. Independent predictors of a prolonged course were age of < 2 years and bilateral acute otitis media. The absolute risk of pain and/or fever at 3 to 7 days for children < 2 years of age with bilateral acute otitis media (20% of all children) was 55%, and that for children > or = 2 years of age with unilateral acute otitis media (47% of all children) was 25%. CONCLUSIONS: The risk of a prolonged course was 2 times higher for children < 2 years of age with bilateral acute otitis media than for children > or = 2 years of age with unilateral acute otitis media. Clinicians can use these features (ie, age of < 2 years and bilateral acute otitis media) to inform parents more explicitly about the expected course of their child's otitis media and to explain which features should prompt parents to contact their clinician for reexamination of the child. |
| spellingShingle | Rovers, M Glasziou, P Appelman, C Burke, P McCormick, D Damoiseaux, R Little, P Le Saux, N Hoes, A Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data. |
| title | Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data. |
| title_full | Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data. |
| title_fullStr | Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data. |
| title_full_unstemmed | Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data. |
| title_short | Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data. |
| title_sort | predictors of pain and or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics a meta analysis of individual patient data |
| work_keys_str_mv | AT roversm predictorsofpainandorfeverat3to7daysforchildrenwithacuteotitismedianottreatedinitiallywithantibioticsametaanalysisofindividualpatientdata AT glaszioup predictorsofpainandorfeverat3to7daysforchildrenwithacuteotitismedianottreatedinitiallywithantibioticsametaanalysisofindividualpatientdata AT appelmanc predictorsofpainandorfeverat3to7daysforchildrenwithacuteotitismedianottreatedinitiallywithantibioticsametaanalysisofindividualpatientdata AT burkep predictorsofpainandorfeverat3to7daysforchildrenwithacuteotitismedianottreatedinitiallywithantibioticsametaanalysisofindividualpatientdata AT mccormickd predictorsofpainandorfeverat3to7daysforchildrenwithacuteotitismedianottreatedinitiallywithantibioticsametaanalysisofindividualpatientdata AT damoiseauxr predictorsofpainandorfeverat3to7daysforchildrenwithacuteotitismedianottreatedinitiallywithantibioticsametaanalysisofindividualpatientdata AT littlep predictorsofpainandorfeverat3to7daysforchildrenwithacuteotitismedianottreatedinitiallywithantibioticsametaanalysisofindividualpatientdata AT lesauxn predictorsofpainandorfeverat3to7daysforchildrenwithacuteotitismedianottreatedinitiallywithantibioticsametaanalysisofindividualpatientdata AT hoesa predictorsofpainandorfeverat3to7daysforchildrenwithacuteotitismedianottreatedinitiallywithantibioticsametaanalysisofindividualpatientdata |