Effects of vaccinia virus anti-inflammatory protein 35K and TIMP-1 gene transfers on vein graft stenosis in rabbits.
BACKGROUND: Vein graft stenosis is a common problem after bypass surgery. Vein grafts are ideal targets for gene therapy because transduction can be made ex vivo before grafting. Since chemokines and inflammatory factors are involved in vein graft thickening, we tested a hypothesis that the vaccini...
المؤلفون الرئيسيون: | Puhakka, H, Turunen, P, Gruchala, M, Bursill, C, Heikura, T, Vajanto, I, Greaves, D, Channons, K, Ylä-Herttuala, S |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2005
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مواد مشابهة
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حسب: Bursill, C, وآخرون
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Adenoviral mediated delivery of a vaccinia viral protein (35K) blocks CC-chemokine activity in vitro and in vivo and may therefore be a useful therapeutic strategy to reduce the initiation and progression of CC-chemokine induced atherosclerosis
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منشور في: (2003) -
Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor.
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