Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension
It is well established that gene interactions influence common human diseases, but to date linkage studies have been constrained to searching for single genes across the genome. We applied a novel approach to uncover significant gene-gene interactions in a systematic two-dimensional (2D) genome-scan...
Үндсэн зохиолчид: | Tzenova Bell, J, Wallace, C, Dobson, R, Wiltshire, S, Mein, C, Pembroke, J, Brown, M, Clayton, D, Samani, N, Dominiczak, A, Webster, J, Lathrop, G, Connell, J, Munroe, P, Caulfield, M, Farrall, M |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
Oxford University Press
2006
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Нөхцлүүд: |
Ижил төстэй зүйлс
Ижил төстэй зүйлс
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Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension.
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Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish Genetics of HyperTension (BRIGHT) study
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