Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension

Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension

Čájet eará veršuvnnaid (1)

It is well established that gene interactions influence common human diseases, but to date linkage studies have been constrained to searching for single genes across the genome. We applied a novel approach to uncover significant gene-gene interactions in a systematic two-dimensional (2D) genome-scan...

Bibliográfalaš dieđut
Váldodahkkit:	Tzenova Bell, J, Wallace, C, Dobson, R, Wiltshire, S, Mein, C, Pembroke, J, Brown, M, Clayton, D, Samani, N, Dominiczak, A, Webster, J, Lathrop, G, Connell, J, Munroe, P, Caulfield, M, Farrall, M
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	Oxford University Press 2006
Fáttát:	Genetics (medical sciences) Cardiovascular disease Medical sciences

Geahča maid

Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension.
Dahkki: Bell, J, et al.
Almmustuhtton: (2006)

Genomewide linkage analysis for loci affecting electrocardiographic LV mass
Dahkki: Padmanabhan, S, et al.
Almmustuhtton: (2006)

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.
Dahkki: Newhouse, S, et al.
Almmustuhtton: (2005)

Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish genetics of Hypertension (BRIGHT) study
Dahkki: Wallace, C, et al.
Almmustuhtton: (2005)

Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish Genetics of HyperTension (BRIGHT) study
Dahkki: Wallace, C, et al.
Almmustuhtton: (2005)

No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study
Dahkki: Newhouse, S, et al.
Almmustuhtton: (2004)

Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension.
Dahkki: Wallace, C, et al.
Almmustuhtton: (2006)

Genome-wide mapping of human loci for essential hypertension.
Dahkki: Caulfield, M, et al.
Almmustuhtton: (2003)

Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study.
Dahkki: Padmanabhan, S, et al.
Almmustuhtton: (2006)

Chromosome 2p shows genome wide significant linkage to of anti-hypertensive medication response in the British genetics of hypertension (BRIGHT) study.
Dahkki: Padmanabhan, S, et al.
Almmustuhtton: (2005)

Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study.
Dahkki: Munroe, P, et al.
Almmustuhtton: (2006)

Novel associations of the Wnk1 gene with risk for essential hypertension and electrolyte homeostasis
Dahkki: Newhouse, S, et al.
Almmustuhtton: (2007)

Association of the WNK1 gene with essential hypertension, blood pressure variability and serum and urine electrolytes
Dahkki: Newhouse, S, et al.
Almmustuhtton: (2007)

Chromosome 2p shows genome wide significant linkage to anti-hypertensive medication response in the British genetics hypertension (BRIGHT) study
Dahkki: Padmanabhan, S, et al.
Almmustuhtton: (2005)

Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism
Dahkki: Fullerton, J, et al.
Almmustuhtton: (2003)

A new tool for checks of data precision within the MRC British genetics of hypertension study
Dahkki: Caulfield, M, et al.
Almmustuhtton: (2000)

Urinary albumin excretion in hypertensive siblings in the British Genetics of Hypertension study
Dahkki: Padmanabhan, S, et al.
Almmustuhtton: (2007)

Enhanced support for linkage to chromosome 5q13.1 and hypertension in the British Genetics of Hypertension (BRIGHT) study.
Dahkki: Munroe, P, et al.
Almmustuhtton: (2005)

Investigation of expression quantitative trait loci and regulatory genetic variants in primary human immune cells
Dahkki: Makino, S
Almmustuhtton: (2013)

Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study.
Dahkki: Munroe, P, et al.
Almmustuhtton: (2000)

WNK1 - functional analyses of variants associated with blood pressure and essential hypertension
Dahkki: Hoti, M, et al.
Almmustuhtton: (2008)

WNK1-functional analyses of variants associated with blood pressure and essential hypertension
Dahkki: Hoti, M, et al.
Almmustuhtton: (2008)

Familial atherosclerotic disease and hypertension localised to chromosome 7p in the British genetics of hypertension study
Dahkki: Padmanabhan, S, et al.
Almmustuhtton: (2006)

Variability of gene expression profiles in human blood and lymphoblastoid cell lines
Dahkki: Min, J, et al.
Almmustuhtton: (2010)

No support for linkage of chromosome 17(q21-24) to Essential Hypertension in the MRC British Genetics of Hypertension (MRC BRIGHT) Study.
Dahkki: Knight, J, et al.
Almmustuhtton: (2001)

Biliary cirrhosis in a child with inherited interleukin-12 deficiency
Dahkki: Pulickal, A, et al.
Almmustuhtton: (2008)

A high-resolution single nucleotide polymorphism genetic map of the mouse genome
Dahkki: Shifman, S, et al.
Almmustuhtton: (2006)

The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD).
Dahkki: Pointon, J, et al.
Almmustuhtton: (2010)

SGCE missense mutations that cause myoclonus-dystonia syndrome impair ε-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA
Dahkki: Esapa, C, et al.
Almmustuhtton: (2007)

Haplotype homozygosity and derived alleles in the human genome
Dahkki: Fry, A, et al.
Almmustuhtton: (2006)

Homozygosity and risk of childhood death due to invasive bacterial disease
Dahkki: Lyons, E, et al.
Almmustuhtton: (2009)

MHC class II proteins and disease: a structural perspective
Dahkki: Jones, E, et al.
Almmustuhtton: (2006)

Interferon lambdas: the next cytokine storm
Dahkki: Kelly, C, et al.
Almmustuhtton: (2011)

The MRC British Genetics of Hypertension Study - Genome-wide screen results
Dahkki: Caulfield, M, et al.
Almmustuhtton: (2002)

Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study
Dahkki: Neil, A, et al.
Almmustuhtton: (2008)

Evidence base of clinical diagnosis: designing studies to ensure that estimates of test accuracy are transferable
Dahkki: Irwig, L, et al.
Almmustuhtton: (2002)

General practitioners' self ratings of skills in evidence based medicine: validation study
Dahkki: Young, J, et al.
Almmustuhtton: (2002)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to Type 2 diabetes
Dahkki: Jafar-Mohammadi, B, et al.
Almmustuhtton: (2009)

Pascasidang Simposium Sains Kesihatan Kebangsaan ketiga, 29 - 30 April 2001, Kuala Lumpur : sains kesihatan untuk alaf baru /
Dahkki: Simposium Sains Kesihatan Kebangsaan (Ke3 : 2000 : UKM, Kuala Lumpur), et al.
Almmustuhtton: (2000)

Medical science : directory of research projects Fundamental Resarch Grant Scheme (FRGS) phase 1/2006
Dahkki: Malaysia. Kementerian Pengajian Tinggi. Jabatan Pengajian Tinggi, issuing body
Almmustuhtton: (2010)