Developmental origins of osteoporotic fracture.

Osteoporosis is a skeletal disorder characterised by low bone mass and micro-architectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture.1 It is a widespread condition, often unrecognised in clinical practice, which may have devastating heal...

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Main Authors: Cooper, C, Westlake, S, Harvey, N, Dennison, E
Format: Journal article
Language:English
Published: 2009
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author Cooper, C
Westlake, S
Harvey, N
Dennison, E
author_facet Cooper, C
Westlake, S
Harvey, N
Dennison, E
author_sort Cooper, C
collection OXFORD
description Osteoporosis is a skeletal disorder characterised by low bone mass and micro-architectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture.1 It is a widespread condition, often unrecognised in clinical practice, which may have devastating health consequences through its association with fragility fractures. The term 'osteoporosis' was first used in the nineteenth century as a histologic description for aged bone tissue, but its clinical consequences were not appreciated until Sir Astley Cooper recognised that hip fractures might result from an age-related reduction in bone mass or quality over 150 years ago. Since one disadvantage of a fracture-based definition is that diagnosis and treatment will be delayed when prevention is considered optimal treatment, an expert panel convened by the World Health Organisation (WHO) has suggested that both low bone mineral density (BMD) and fracture be combined in a stratified definition of osteoporosis.2 © 2009 Springer Netherlands.
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spelling oxford-uuid:3c30b3d0-fdc4-4ca9-85cb-b6c48141ad6a2022-03-26T14:12:09ZDevelopmental origins of osteoporotic fracture.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3c30b3d0-fdc4-4ca9-85cb-b6c48141ad6aEnglishSymplectic Elements at Oxford2009Cooper, CWestlake, SHarvey, NDennison, EOsteoporosis is a skeletal disorder characterised by low bone mass and micro-architectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture.1 It is a widespread condition, often unrecognised in clinical practice, which may have devastating health consequences through its association with fragility fractures. The term 'osteoporosis' was first used in the nineteenth century as a histologic description for aged bone tissue, but its clinical consequences were not appreciated until Sir Astley Cooper recognised that hip fractures might result from an age-related reduction in bone mass or quality over 150 years ago. Since one disadvantage of a fracture-based definition is that diagnosis and treatment will be delayed when prevention is considered optimal treatment, an expert panel convened by the World Health Organisation (WHO) has suggested that both low bone mineral density (BMD) and fracture be combined in a stratified definition of osteoporosis.2 © 2009 Springer Netherlands.
spellingShingle Cooper, C
Westlake, S
Harvey, N
Dennison, E
Developmental origins of osteoporotic fracture.
title Developmental origins of osteoporotic fracture.
title_full Developmental origins of osteoporotic fracture.
title_fullStr Developmental origins of osteoporotic fracture.
title_full_unstemmed Developmental origins of osteoporotic fracture.
title_short Developmental origins of osteoporotic fracture.
title_sort developmental origins of osteoporotic fracture
work_keys_str_mv AT cooperc developmentaloriginsofosteoporoticfracture
AT westlakes developmentaloriginsofosteoporoticfracture
AT harveyn developmentaloriginsofosteoporoticfracture
AT dennisone developmentaloriginsofosteoporoticfracture