AAV-mediated gene transfer of human X-linked inhibitor of apoptosis protects against oxidative cell death in human RPE cells

Purpose. To determine whether human X-linked inhibitor of apoptosis (XIAP) enhances the survival of cultured human retinal pigment epithelial cells exposed to H 2O 2. Methods. ARPE-19 cells were exposed to H 2O 2 to induce oxidative cell death. Intracellular reactive oxygen species (ROS) were measur...

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Bibliographic Details
Main Authors: Shan, H, Ji, D, Barnard, A, Lipinski, D, You, Q, Lee, E, Kamalden, T, Sun, X, MacLaren, R
Format: Journal article
Language:English
Published: 2011