Stereoselective methodology for 1-aryl-1-alkyl epoxides via chromium tricarbonyl complexes
Treatment of (1RS, SSR)-(1-phenylsulfinyl-2-valeryl benzene) chromium tricarbonyl 2 with a sulfur ylide results in a highly diastereoselective epoxide formation (d.s.>96:4). Regioselective opening of the epoxide, employing an in situ trapping protocol, allows the synthesis of a highly functio...
| Hoofdauteurs: | , , |
|---|---|
| Formaat: | Journal article |
| Gepubliceerd in: |
1997
|
| Samenvatting: | Treatment of (1RS, SSR)-(1-phenylsulfinyl-2-valeryl benzene) chromium tricarbonyl 2 with a sulfur ylide results in a highly diastereoselective epoxide formation (d.s.>96:4). Regioselective opening of the epoxide, employing an in situ trapping protocol, allows the synthesis of a highly functionalised, diastereomerically pure benzylic alcohol. |
|---|