Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells.
Tau is a neuronal microtubule-associated protein whose function is modulated by phosphorylation. GSK-3beta is a tau kinase. GSK-3beta is part of the wingless signalling pathway and stimulation by wingless is predicted to down-regulate GSK-3beta activity. In Drosophila imaginal disc cells, overexpres...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1797063816597471232 |
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| author | Wagner, U Brownlees, J Irving, N Lucas, F Salinas, P Miller, C |
| author_facet | Wagner, U Brownlees, J Irving, N Lucas, F Salinas, P Miller, C |
| author_sort | Wagner, U |
| collection | OXFORD |
| description | Tau is a neuronal microtubule-associated protein whose function is modulated by phosphorylation. GSK-3beta is a tau kinase. GSK-3beta is part of the wingless signalling pathway and stimulation by wingless is predicted to down-regulate GSK-3beta activity. In Drosophila imaginal disc cells, overexpression of dishevelled, a component of the wingless pathway, mimics the wingless signal. We have therefore studied the effect that overexpression of the murine dishevelled-1 protein has on GSK-3beta-mediated phosphorylation of tau in transfected CHO cells. We find that co-transfection with dishevelled-1 is inhibitory to GSK-3beta-mediated tau phosphorylation. Tau is hyperphosphorylated in Alzheimer's disease and the possible relevance of these findings to Alzheimer's disease pathogenesis are discussed. |
| first_indexed | 2024-03-06T21:05:20Z |
| format | Journal article |
| id | oxford-uuid:3c3e81ab-2a0f-44c4-8aea-f1d6ee51ec94 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:05:20Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:3c3e81ab-2a0f-44c4-8aea-f1d6ee51ec942022-03-26T14:12:29ZOverexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3c3e81ab-2a0f-44c4-8aea-f1d6ee51ec94EnglishSymplectic Elements at Oxford1997Wagner, UBrownlees, JIrving, NLucas, FSalinas, PMiller, CTau is a neuronal microtubule-associated protein whose function is modulated by phosphorylation. GSK-3beta is a tau kinase. GSK-3beta is part of the wingless signalling pathway and stimulation by wingless is predicted to down-regulate GSK-3beta activity. In Drosophila imaginal disc cells, overexpression of dishevelled, a component of the wingless pathway, mimics the wingless signal. We have therefore studied the effect that overexpression of the murine dishevelled-1 protein has on GSK-3beta-mediated phosphorylation of tau in transfected CHO cells. We find that co-transfection with dishevelled-1 is inhibitory to GSK-3beta-mediated tau phosphorylation. Tau is hyperphosphorylated in Alzheimer's disease and the possible relevance of these findings to Alzheimer's disease pathogenesis are discussed. |
| spellingShingle | Wagner, U Brownlees, J Irving, N Lucas, F Salinas, P Miller, C Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells. |
| title | Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells. |
| title_full | Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells. |
| title_fullStr | Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells. |
| title_full_unstemmed | Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells. |
| title_short | Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells. |
| title_sort | overexpression of the mouse dishevelled 1 protein inhibits gsk 3beta mediated phosphorylation of tau in transfected mammalian cells |
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