Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010
Background: The annual incidence and temporal trend of severe malaria and community-acquired bacteraemia during a four-year period in Muheza, Tanzania was assessed. Methods. Data on severely ill febrile children aged 2 months to 14 years from three prospective studies conducted at Muheza District Ho...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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BioMed Central
2011
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| _version_ | 1826268165250744320 |
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| author | Mtove, G Amos, B Nadjm, B Hendriksen, I Dondorp, A Mwambuli, A Kim, DR Ochiai, R Clemens, J Von Seidlein, L Reyburn, H Deen, J |
| author_facet | Mtove, G Amos, B Nadjm, B Hendriksen, I Dondorp, A Mwambuli, A Kim, DR Ochiai, R Clemens, J Von Seidlein, L Reyburn, H Deen, J |
| author_sort | Mtove, G |
| collection | OXFORD |
| description | Background: The annual incidence and temporal trend of severe malaria and community-acquired bacteraemia during a four-year period in Muheza, Tanzania was assessed. Methods. Data on severely ill febrile children aged 2 months to 14 years from three prospective studies conducted at Muheza District Hospital from 2006 to 2010 was pooled and analysed. On admission, each enrolled child had a thin and thick blood film and at least one rapid diagnostic test for falciparum malaria, as well as a blood culture. The annual incidence of bacteraemia and severe malaria among children coming from Muheza was calculated and their temporal trend was assessed. Results: Overall, 1, 898 severe falciparum malaria and 684 bacteraemia cases were included. Of these, 1, 356 (71%) and 482 (71%), respectively, were from the referral population of Muheza. The incidence of falciparum malaria and all-cause bacteraemia in Muheza decreased five-fold and three-fold, respectively, from the first to the fourth year of surveillance (p < 0.0001). During this period, the median ages of children from Muheza admitted with severe malaria increased from 1.7 to 2.5 years (p < 0.0001). The reduction in all-cause bacteraemia was mainly driven by the 11-fold decline in the incidence of non-typhoidal salmonellosis. The annual incidences of Haemophilus influenzae and pneumococcal invasive bacterial infections decreased as well but were much fewer in number. Conclusions: These results add to the growing evidence of the decline in malaria associated with a decrease in non-typhoidal salmonellosis and possibly other bacteraemias. Malarial prevention and control strategies may provide a greater benefit than the mere reduction of malaria alone. © 2011Mtove et al; licensee BioMed Central Ltd. |
| first_indexed | 2024-03-06T21:05:26Z |
| format | Journal article |
| id | oxford-uuid:3c4a5b40-c678-48d7-a8ff-6ad0c37d4fc8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:05:26Z |
| publishDate | 2011 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:3c4a5b40-c678-48d7-a8ff-6ad0c37d4fc82022-03-26T14:12:46ZDecreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3c4a5b40-c678-48d7-a8ff-6ad0c37d4fc8EnglishSymplectic Elements at OxfordBioMed Central2011Mtove, GAmos, BNadjm, BHendriksen, IDondorp, AMwambuli, AKim, DROchiai, RClemens, JVon Seidlein, LReyburn, HDeen, JBackground: The annual incidence and temporal trend of severe malaria and community-acquired bacteraemia during a four-year period in Muheza, Tanzania was assessed. Methods. Data on severely ill febrile children aged 2 months to 14 years from three prospective studies conducted at Muheza District Hospital from 2006 to 2010 was pooled and analysed. On admission, each enrolled child had a thin and thick blood film and at least one rapid diagnostic test for falciparum malaria, as well as a blood culture. The annual incidence of bacteraemia and severe malaria among children coming from Muheza was calculated and their temporal trend was assessed. Results: Overall, 1, 898 severe falciparum malaria and 684 bacteraemia cases were included. Of these, 1, 356 (71%) and 482 (71%), respectively, were from the referral population of Muheza. The incidence of falciparum malaria and all-cause bacteraemia in Muheza decreased five-fold and three-fold, respectively, from the first to the fourth year of surveillance (p < 0.0001). During this period, the median ages of children from Muheza admitted with severe malaria increased from 1.7 to 2.5 years (p < 0.0001). The reduction in all-cause bacteraemia was mainly driven by the 11-fold decline in the incidence of non-typhoidal salmonellosis. The annual incidences of Haemophilus influenzae and pneumococcal invasive bacterial infections decreased as well but were much fewer in number. Conclusions: These results add to the growing evidence of the decline in malaria associated with a decrease in non-typhoidal salmonellosis and possibly other bacteraemias. Malarial prevention and control strategies may provide a greater benefit than the mere reduction of malaria alone. © 2011Mtove et al; licensee BioMed Central Ltd. |
| spellingShingle | Mtove, G Amos, B Nadjm, B Hendriksen, I Dondorp, A Mwambuli, A Kim, DR Ochiai, R Clemens, J Von Seidlein, L Reyburn, H Deen, J Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
| title | Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
| title_full | Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
| title_fullStr | Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
| title_full_unstemmed | Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
| title_short | Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010 |
| title_sort | decreasing incidence of severe malaria and community acquired bacteraemia among hospitalized children in muheza north eastern tanzania 2006 2010 |
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