Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.

Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.

1. The beta-cell K(ATP) channel is composed of two types of subunit - the inward rectifier K(+) channel (Kir6.2) which forms the channel pore, and the sulphonylurea receptor (SUR1), which serves as a regulatory subunit. The N-terminus of Kir6.2 is involved in transduction of sulphonylurea binding in...

Bibliografiset tiedot
Päätekijät:	Hansen, A, Hansen, J, Carr, R, Ashcroft, F, Wahl, P
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2005

Samankaltaisia teoksia

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Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels.
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The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15 beta-cells.
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Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).
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Structure-function studies of the fast gating kinetics of the cloned ATP-sensitive potassium channel, Kir6.2/SUR1
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