Regulatory T cells in transplantation tolerance.
The identification and characterization of regulatory T (T(Reg)) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1797063852743983104 |
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| author | Wood, K Sakaguchi, S |
| author_facet | Wood, K Sakaguchi, S |
| author_sort | Wood, K |
| collection | OXFORD |
| description | The identification and characterization of regulatory T (T(Reg)) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25. In vivo, common mechanisms seem to underpin the activity of CD4+CD25+ T(Reg) cells in both naive and manipulated hosts. However, the origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ T(Reg) cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate.. |
| first_indexed | 2024-03-06T21:05:53Z |
| format | Journal article |
| id | oxford-uuid:3c701cbf-5527-449b-ab38-618c0cfd8f4a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:05:53Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:3c701cbf-5527-449b-ab38-618c0cfd8f4a2022-03-26T14:13:37ZRegulatory T cells in transplantation tolerance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3c701cbf-5527-449b-ab38-618c0cfd8f4aEnglishSymplectic Elements at Oxford2003Wood, KSakaguchi, SThe identification and characterization of regulatory T (T(Reg)) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25. In vivo, common mechanisms seem to underpin the activity of CD4+CD25+ T(Reg) cells in both naive and manipulated hosts. However, the origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ T(Reg) cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate.. |
| spellingShingle | Wood, K Sakaguchi, S Regulatory T cells in transplantation tolerance. |
| title | Regulatory T cells in transplantation tolerance. |
| title_full | Regulatory T cells in transplantation tolerance. |
| title_fullStr | Regulatory T cells in transplantation tolerance. |
| title_full_unstemmed | Regulatory T cells in transplantation tolerance. |
| title_short | Regulatory T cells in transplantation tolerance. |
| title_sort | regulatory t cells in transplantation tolerance |
| work_keys_str_mv | AT woodk regulatorytcellsintransplantationtolerance AT sakaguchis regulatorytcellsintransplantationtolerance |