Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice.

Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice.

(6R)-5,6,7,8-Tetrahydro-biopterin (H(4)B) is essential for the catalytic activity of all NO synthases. The hyperphenylalaninemic mouse mutant (hph-1) displays 90% deficiency of the GTP cyclohydrolase I, the rate-limiting enzyme in H(4)B synthesis. A relative shortage of H(4)B may shift the balance b...

Full description

Bibliographic Details
Main Authors:	Cosentino, F, Barker, J, Brand, M, Heales, S, Werner, E, Tippins, JR, West, N, Channon, K, Volpe, M, Lüscher, T
Format:	Journal article
Language:	English
Published:	2001

Similar Items

Correction of tetrahydrobiopterin deficiency - Implications for dopa responsive dystonia and other inherited disorders of tetrahydrobiopterin metabolism
by: Heales, S, et al.
Published: (2005)

Tetrahydrobiopterin deficiency increases susceptibility to atherosclerosis
by: Khoo, J, et al.
Published: (2005)

Reactive oxygen species-induced impairment of endothelium-dependent relaxations in rat aortic rings: protection by methanolic extracts of phoebe grandis
by: Lau, Yeh-Siang, et al.
Published: (2011)

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice
by: Chuaiphichai, S, et al.
Published: (2017)

Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia.
by: Cosentino, F, et al.
Published: (2008)

Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.
by: Chuaiphichai, S, et al.
Published: (2023)

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
by: Alp, N, et al.
Published: (2002)

Mast cell tetrahydrobiopterin contributes to itch in mice
by: Zschiebsch, K, et al.
Published: (2018)

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
by: Khoo, J, et al.
Published: (2004)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
by: Khoo, J, et al.
Published: (2004)

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension
by: Chuaiphichai, S, et al.
Published: (2015)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
by: Crabtree, M, et al.
Published: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
by: Crabtree, M, et al.
Published: (2011)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
by: Khoo, J, et al.
Published: (2005)

The endothelium and the pathogenesis of atherosclerosis
by: Channon, K
Published: (2006)

The endothelium and the pathogenesis of atherosclerosis
by: Channon, K
Published: (2002)

Measurement of vascular reactive oxygen species production by chemiluminescence.
by: Guzik, T, et al.
Published: (2005)

Increased endothelial tetrahydrobiopterin reduces in stent stenosis in apolipoprotein E-knockout mice
by: Ali, Z, et al.
Published: (2007)

Increased Endothelial Tetrahydrobiopterin Reduces In Stent Stenosis in Apolipoprotein E-Knockout Mice
by: Ali, Z, et al.
Published: (2011)

Reactive Oxygen Species
by: Ryan, B, et al.
Published: (2015)

Hypoxic relaxation of penile arteries: involvement of endothelial nitric oxide and modulation by reactive oxygen species.
by: Prieto, D, et al.
Published: (2010)

The % tetrahydrobiopterin (BH4) and serine 1177 phosphorylation 19 reduced in sickle transgenic mice
by: Chen, Q, et al.
Published: (2007)

Hyperpolarization and relaxation of vascular smooth muscle to endothelium-derived nitric oxide
by: Cohen, R, et al.
Published: (1999)

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
by: Schmidt, T, et al.
Published: (2010)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
by: Cai, S, et al.
Published: (2005)

Increased endothelial tetrahydrobiopterin levels by GTPCH over expression in transgenic mice prevents diabetic endothelial dysfunction
by: Alp, N, et al.
Published: (2003)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
by: Carnicer, R, et al.
Published: (2012)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
by: Carnicer, R, et al.
Published: (2012)

Tetrahydrobiopterin and nitric oxide synthase recouplers
by: Channon, KM
Published: (2020)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
by: Ali, Z, et al.
Published: (2005)

Tetrahydrobiopterin: Pleiotropic roles in cardiovascular pathophysiology
by: Cunnington, C, et al.
Published: (2010)

Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology.
by: Cunnington, C, et al.
Published: (2010)

Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling
by: Khoo, J, et al.
Published: (2004)

The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
by: McNeill, E, et al.
Published: (2012)

Endothelial cell tetrahydrobiopterin: going with the flow.
by: De Bono, J, et al.
Published: (2007)

Tetrahydrobiopterin in cardiovascular health and disease.
by: Bendall, J, et al.
Published: (2014)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft accelerated atherosclerosis in apolipoprotein E-knockout mice
by: Ali, Z, et al.
Published: (2006)

Mitochondrial reactive oxygen species and cancer
by: Chandel, Navdeep S, et al.
Published: (2014)

Reactive oxygen species and airway hypereactivity
by: , DOELMAN, Cornelis Jan Arie, et al.
Published: (1991)

Regulation of eNOS function by tetrahydrobiopterin in vascular disease
by: Channon, K
Published: (2004)