Persons ‘never treated’ in mass drug administration for lymphatic filariasis: identifying programmatic and research needs from a series of research review meetings 2020–2021

As neglected tropical disease programs rely on participation in rounds of mass drug administration (MDA), there is concern that individuals who have never been treated could contribute to ongoing transmission, posing a barrier to elimination. Previous research has suggested that the size and charact...

Full description

Bibliographic Details
Main Authors: Brady, MA, Toubali, E, Baker, M, Long, E, Worrell, C, Ramaiah, K, Graves, P, Hollingsworth, TD, Kelly-Hope, L, Stukel, D, Tripathi, B, Means, AR, Matendechero, SH, Krentel, A
Format: Journal article
Language:English
Published: Oxford University Press 2023
_version_ 1811141141835284480
author Brady, MA
Toubali, E
Baker, M
Long, E
Worrell, C
Ramaiah, K
Graves, P
Hollingsworth, TD
Kelly-Hope, L
Stukel, D
Tripathi, B
Means, AR
Matendechero, SH
Krentel, A
author_facet Brady, MA
Toubali, E
Baker, M
Long, E
Worrell, C
Ramaiah, K
Graves, P
Hollingsworth, TD
Kelly-Hope, L
Stukel, D
Tripathi, B
Means, AR
Matendechero, SH
Krentel, A
author_sort Brady, MA
collection OXFORD
description As neglected tropical disease programs rely on participation in rounds of mass drug administration (MDA), there is concern that individuals who have never been treated could contribute to ongoing transmission, posing a barrier to elimination. Previous research has suggested that the size and characteristics of the never-treated population may be important but have not been sufficiently explored. To address this critical knowledge gap, four meetings were held from December 2020 to May 2021 to compile expert knowledge on never treatment in lymphatic filariasis (LF) MDA programs. The meetings explored four questions: the number and proportion of people never treated, their sociodemographic characteristics, their infection status and the reasons why they were not treated. Meeting discussions noted key issues requiring further exploration, including how to standardize measurement of the never treated, adapt and use existing tools to capture never-treated data and ensure representation of never-treated people in data collection. Recognizing that patterns of never treatment are situation specific, participants noted measurement should be quick, inexpensive and focused on local solutions. Furthermore, programs should use existing data to generate mathematical models to understand what levels of never treatment may compromise LF elimination goals or trigger programmatic action.
first_indexed 2024-09-25T04:33:10Z
format Journal article
id oxford-uuid:3c8288ed-5b2f-40f2-b334-898cf8e8ef25
institution University of Oxford
language English
last_indexed 2024-09-25T04:33:10Z
publishDate 2023
publisher Oxford University Press
record_format dspace
spelling oxford-uuid:3c8288ed-5b2f-40f2-b334-898cf8e8ef252024-09-05T20:09:37ZPersons ‘never treated’ in mass drug administration for lymphatic filariasis: identifying programmatic and research needs from a series of research review meetings 2020–2021Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3c8288ed-5b2f-40f2-b334-898cf8e8ef25EnglishJisc Publications RouterOxford University Press2023Brady, MAToubali, EBaker, MLong, EWorrell, CRamaiah, KGraves, PHollingsworth, TDKelly-Hope, LStukel, DTripathi, BMeans, ARMatendechero, SHKrentel, AAs neglected tropical disease programs rely on participation in rounds of mass drug administration (MDA), there is concern that individuals who have never been treated could contribute to ongoing transmission, posing a barrier to elimination. Previous research has suggested that the size and characteristics of the never-treated population may be important but have not been sufficiently explored. To address this critical knowledge gap, four meetings were held from December 2020 to May 2021 to compile expert knowledge on never treatment in lymphatic filariasis (LF) MDA programs. The meetings explored four questions: the number and proportion of people never treated, their sociodemographic characteristics, their infection status and the reasons why they were not treated. Meeting discussions noted key issues requiring further exploration, including how to standardize measurement of the never treated, adapt and use existing tools to capture never-treated data and ensure representation of never-treated people in data collection. Recognizing that patterns of never treatment are situation specific, participants noted measurement should be quick, inexpensive and focused on local solutions. Furthermore, programs should use existing data to generate mathematical models to understand what levels of never treatment may compromise LF elimination goals or trigger programmatic action.
spellingShingle Brady, MA
Toubali, E
Baker, M
Long, E
Worrell, C
Ramaiah, K
Graves, P
Hollingsworth, TD
Kelly-Hope, L
Stukel, D
Tripathi, B
Means, AR
Matendechero, SH
Krentel, A
Persons ‘never treated’ in mass drug administration for lymphatic filariasis: identifying programmatic and research needs from a series of research review meetings 2020–2021
title Persons ‘never treated’ in mass drug administration for lymphatic filariasis: identifying programmatic and research needs from a series of research review meetings 2020–2021
title_full Persons ‘never treated’ in mass drug administration for lymphatic filariasis: identifying programmatic and research needs from a series of research review meetings 2020–2021
title_fullStr Persons ‘never treated’ in mass drug administration for lymphatic filariasis: identifying programmatic and research needs from a series of research review meetings 2020–2021
title_full_unstemmed Persons ‘never treated’ in mass drug administration for lymphatic filariasis: identifying programmatic and research needs from a series of research review meetings 2020–2021
title_short Persons ‘never treated’ in mass drug administration for lymphatic filariasis: identifying programmatic and research needs from a series of research review meetings 2020–2021
title_sort persons never treated in mass drug administration for lymphatic filariasis identifying programmatic and research needs from a series of research review meetings 2020 2021
work_keys_str_mv AT bradyma personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT toubalie personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT bakerm personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT longe personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT worrellc personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT ramaiahk personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT gravesp personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT hollingsworthtd personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT kellyhopel personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT stukeld personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT tripathib personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT meansar personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT matendecherosh personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021
AT krentela personsnevertreatedinmassdrugadministrationforlymphaticfilariasisidentifyingprogrammaticandresearchneedsfromaseriesofresearchreviewmeetings20202021