Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK.
UNLABELLED: BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK. RESULTS: Complications of intraventricular catheterization were frequent. PPS w...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797063919310733312 |
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| author | Bone, I Belton, L Walker, A Darbyshire, J |
| author_facet | Bone, I Belton, L Walker, A Darbyshire, J |
| author_sort | Bone, I |
| collection | OXFORD |
| description | UNLABELLED: BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK. RESULTS: Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 microg/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly. CONCLUSION: Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored. |
| first_indexed | 2024-03-06T21:06:51Z |
| format | Journal article |
| id | oxford-uuid:3cc3f19f-4f34-4243-a1c3-02e3213b82ca |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:06:51Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:3cc3f19f-4f34-4243-a1c3-02e3213b82ca2022-03-26T14:15:32ZIntraventricular pentosan polysulphate in human prion diseases: an observational study in the UK.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3cc3f19f-4f34-4243-a1c3-02e3213b82caEnglishSymplectic Elements at Oxford2008Bone, IBelton, LWalker, ADarbyshire, J UNLABELLED: BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK. RESULTS: Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 microg/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly. CONCLUSION: Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored. |
| spellingShingle | Bone, I Belton, L Walker, A Darbyshire, J Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK. |
| title | Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK. |
| title_full | Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK. |
| title_fullStr | Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK. |
| title_full_unstemmed | Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK. |
| title_short | Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK. |
| title_sort | intraventricular pentosan polysulphate in human prion diseases an observational study in the uk |
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