Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching
BACKGROUND: Acetylation of lysine residues in histone tails plays an important role in the regulation of gene transcription. Bromdomains are the readers of acetylated histone marks, and, consequently, bromodomain-containing proteins have a variety of chromatin-related functions. Moreover, they are i...
Main Authors: | Philpott, M, Rogers, C, Yapp, C, Wells, C, Lambert, J, Strain-Damerell, C, Burgess-Brown, N, Gingras, A, Knapp, S, Müller, S |
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Format: | Journal article |
Language: | English |
Published: |
BioMed Central
2014
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