Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients’ health-related quality of life and productivity
<p>Background: Although psoriatic arthritis is complex and involves multiple domains, recent advances in treatments have made remission or near-remission of most symptoms a potentially achievable goal for many patients. We sought to evaluate whether achieving minimal disease activity (MDA) cri...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
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BioMed Central
2018
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| _version_ | 1797063934295932928 |
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| author | Coates, L Orbai, A Morita, A Benichou, O Kerr, L Adams, D Shuler, C Birt, J Helliwell, P |
| author_facet | Coates, L Orbai, A Morita, A Benichou, O Kerr, L Adams, D Shuler, C Birt, J Helliwell, P |
| author_sort | Coates, L |
| collection | OXFORD |
| description | <p>Background: Although psoriatic arthritis is complex and involves multiple domains, recent advances in treatments have made remission or near-remission of most symptoms a potentially achievable goal for many patients. We sought to evaluate whether achieving minimal disease activity (MDA) criteria represented meaningful improvement from the patient perspective. </p><p> Methods: Data were combined from two randomized, multinational, 24 week clinical studies of ixekizumab, a high-affinity monoclonal antibody selectively targeting interleukin-17A, in biological drug-naïve or experienced adults. MDA required 5 of 7 of: tender joint count ≤1; swollen joint count ≤1; Psoriasis Area and Severity Index total score ≤1 or body surface area ≤3%; patient’s assessment of pain visual analogue scale (VAS) ≤15; patient’s global assessment of disease activity VAS ≤20; Health Assessment Questionnaire Disability Index ≤0.5; and tender entheseal points ≤1. MDA responders and non-responders were compared for mean change from baseline on the 36-Item Short Form Health Survey (SF-36), European Quality of Life 5 Dimension 5 Level Health Questionnaire (EQ-5D-5L); EQ-5D-5L VAS; and Work Productivity and Activity Impairment–Specific Health Problem (WPAI-SHP) questionnaire.</p><p> Results: MDA responders had significantly greater improvements versus non-responders in each SF-36 domain and in the SF-36 physical summary score; improvements were also greater in the EQ-5D-5L and EQ-5D-5L VAS, and in 3 of the 4 WPAI-SHP domains. MDA responders were more likely to achieve minimal clinically important differences than non-responders.</p><p> Conclusion: These findings support MDA response as being strongly associated with achieving improved disease status based on measures of patient reported health-related quality of life and productivity. </p> |
| first_indexed | 2024-03-06T21:07:04Z |
| format | Journal article |
| id | oxford-uuid:3cd74aae-c069-48c4-aa74-4ee01a2b052d |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:07:04Z |
| publishDate | 2018 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:3cd74aae-c069-48c4-aa74-4ee01a2b052d2022-03-26T14:15:59ZAchieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients’ health-related quality of life and productivityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3cd74aae-c069-48c4-aa74-4ee01a2b052dSymplectic Elements at OxfordBioMed Central2018Coates, LOrbai, AMorita, ABenichou, OKerr, LAdams, DShuler, CBirt, JHelliwell, P<p>Background: Although psoriatic arthritis is complex and involves multiple domains, recent advances in treatments have made remission or near-remission of most symptoms a potentially achievable goal for many patients. We sought to evaluate whether achieving minimal disease activity (MDA) criteria represented meaningful improvement from the patient perspective. </p><p> Methods: Data were combined from two randomized, multinational, 24 week clinical studies of ixekizumab, a high-affinity monoclonal antibody selectively targeting interleukin-17A, in biological drug-naïve or experienced adults. MDA required 5 of 7 of: tender joint count ≤1; swollen joint count ≤1; Psoriasis Area and Severity Index total score ≤1 or body surface area ≤3%; patient’s assessment of pain visual analogue scale (VAS) ≤15; patient’s global assessment of disease activity VAS ≤20; Health Assessment Questionnaire Disability Index ≤0.5; and tender entheseal points ≤1. MDA responders and non-responders were compared for mean change from baseline on the 36-Item Short Form Health Survey (SF-36), European Quality of Life 5 Dimension 5 Level Health Questionnaire (EQ-5D-5L); EQ-5D-5L VAS; and Work Productivity and Activity Impairment–Specific Health Problem (WPAI-SHP) questionnaire.</p><p> Results: MDA responders had significantly greater improvements versus non-responders in each SF-36 domain and in the SF-36 physical summary score; improvements were also greater in the EQ-5D-5L and EQ-5D-5L VAS, and in 3 of the 4 WPAI-SHP domains. MDA responders were more likely to achieve minimal clinically important differences than non-responders.</p><p> Conclusion: These findings support MDA response as being strongly associated with achieving improved disease status based on measures of patient reported health-related quality of life and productivity. </p> |
| spellingShingle | Coates, L Orbai, A Morita, A Benichou, O Kerr, L Adams, D Shuler, C Birt, J Helliwell, P Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients’ health-related quality of life and productivity |
| title | Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients’ health-related quality of life and productivity |
| title_full | Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients’ health-related quality of life and productivity |
| title_fullStr | Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients’ health-related quality of life and productivity |
| title_full_unstemmed | Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients’ health-related quality of life and productivity |
| title_short | Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients’ health-related quality of life and productivity |
| title_sort | achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients health related quality of life and productivity |
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