Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans.
The effect of spontaneous beat-to-beat mean arterial blood pressure fluctuations and breath-to-breath end-tidal CO2 fluctuations on beat-to-beat cerebral blood flow velocity variations is studied using the Laguerre-Volterra network methodology for multiple-input nonlinear systems. The observations m...
| Päätekijät: | , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
2004
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| _version_ | 1826268284244197376 |
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| author | Mitsis, G Poulin, M Robbins, P Marmarelis, V |
| author_facet | Mitsis, G Poulin, M Robbins, P Marmarelis, V |
| author_sort | Mitsis, G |
| collection | OXFORD |
| description | The effect of spontaneous beat-to-beat mean arterial blood pressure fluctuations and breath-to-breath end-tidal CO2 fluctuations on beat-to-beat cerebral blood flow velocity variations is studied using the Laguerre-Volterra network methodology for multiple-input nonlinear systems. The observations made from experimental measurements from ten healthy human subjects reveal that, whereas pressure fluctuations explain most of the high-frequency blood flow velocity variations (above 0.04 Hz), end-tidal CO2 fluctuations as well as nonlinear interactions between pressure and CO2 have a considerable effect in the lower frequencies (below 0.04 Hz). They also indicate that cerebral autoregulation is strongly nonlinear and dynamic (frequency-dependent). Nonlinearities are mainly active in the low-frequency range (below 0.04 Hz) and are more prominent in the dynamics of the end-tidal CO2-blood flow velocity relationship. Significant nonstationarities are also revealed by the obtained models, with greater variability evident for the effects of CO2 on blood flow velocity dynamics. |
| first_indexed | 2024-03-06T21:07:19Z |
| format | Journal article |
| id | oxford-uuid:3cea02ae-e3c3-4a3f-aa02-db7bbd4a3482 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:07:19Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:3cea02ae-e3c3-4a3f-aa02-db7bbd4a34822022-03-26T14:16:26ZNonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3cea02ae-e3c3-4a3f-aa02-db7bbd4a3482EnglishSymplectic Elements at Oxford2004Mitsis, GPoulin, MRobbins, PMarmarelis, VThe effect of spontaneous beat-to-beat mean arterial blood pressure fluctuations and breath-to-breath end-tidal CO2 fluctuations on beat-to-beat cerebral blood flow velocity variations is studied using the Laguerre-Volterra network methodology for multiple-input nonlinear systems. The observations made from experimental measurements from ten healthy human subjects reveal that, whereas pressure fluctuations explain most of the high-frequency blood flow velocity variations (above 0.04 Hz), end-tidal CO2 fluctuations as well as nonlinear interactions between pressure and CO2 have a considerable effect in the lower frequencies (below 0.04 Hz). They also indicate that cerebral autoregulation is strongly nonlinear and dynamic (frequency-dependent). Nonlinearities are mainly active in the low-frequency range (below 0.04 Hz) and are more prominent in the dynamics of the end-tidal CO2-blood flow velocity relationship. Significant nonstationarities are also revealed by the obtained models, with greater variability evident for the effects of CO2 on blood flow velocity dynamics. |
| spellingShingle | Mitsis, G Poulin, M Robbins, P Marmarelis, V Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans. |
| title | Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans. |
| title_full | Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans. |
| title_fullStr | Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans. |
| title_full_unstemmed | Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans. |
| title_short | Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans. |
| title_sort | nonlinear modeling of the dynamic effects of arterial pressure and co2 variations on cerebral blood flow in healthy humans |
| work_keys_str_mv | AT mitsisg nonlinearmodelingofthedynamiceffectsofarterialpressureandco2variationsoncerebralbloodflowinhealthyhumans AT poulinm nonlinearmodelingofthedynamiceffectsofarterialpressureandco2variationsoncerebralbloodflowinhealthyhumans AT robbinsp nonlinearmodelingofthedynamiceffectsofarterialpressureandco2variationsoncerebralbloodflowinhealthyhumans AT marmarelisv nonlinearmodelingofthedynamiceffectsofarterialpressureandco2variationsoncerebralbloodflowinhealthyhumans |