| Итог: | An iridium-catalyzed, reductive alkylation of abundant tertiary lactams and amides using 1-2 mol % of Vaska's complex (IrCl(CO)(PPh<sub>3</sub>)<sub>2</sub>), tetramethyldisiloxane (TMDS), and difluoro-Reformatsky reagents (BrZnCF<sub>2</sub>R) for the general synthesis of medicinally relevant α-difluoroalkylated tertiary amines is described. A broad scope (46 examples), including <i>N</i>-aryl- and <i>N</i>-heteroaryl-substituted lactams, demonstrated an excellent functional group tolerance. Furthermore, late-stage drug functionalizations, a gram-scale synthesis, and common downstream transformations proved the potential synthetic relevance of this new methodology.
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