Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.

Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.

We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during the critical first weeks of infection. Previous studies suggested that a single...

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Bibliographic Details
Main Authors: Fischer, W, Ganusov, V, Giorgi, E, Hraber, P, Keele, B, Leitner, T, Han, C, Gleasner, C, Green, L, Lo, C, Nag, A, Wallstrom, T, Wang, S, McMichael, A, Haynes, B, Hahn, B, Perelson, A, Borrow, P, Shaw, G, Bhattacharya, T, Korber, B
Format: Journal article
Language:English
Published: Public Library of Science 2010

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