Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.
We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during the critical first weeks of infection. Previous studies suggested that a single...
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Fformat: | Journal article |
Iaith: | English |
Cyhoeddwyd: |
Public Library of Science
2010
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