Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp.
We postulated that changes in cardiac high-energy phosphate metabolism may underlie the myocardial dysfunction caused by hypobaric hypoxia. Healthy volunteers (n=14) were studied immediately before, and within 4 d of return from, a 17-d trek to Mt. Everest Base Camp (5300 m). (31)P magnetic resonanc...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1797063979757993984 |
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| author | Holloway, C Montgomery, H Murray, A Cochlin, L Codreanu, I Hopwood, N Johnson, A Rider, O Levett, D Tyler, D Francis, J Neubauer, S Grocott, M Clarke, K |
| author_facet | Holloway, C Montgomery, H Murray, A Cochlin, L Codreanu, I Hopwood, N Johnson, A Rider, O Levett, D Tyler, D Francis, J Neubauer, S Grocott, M Clarke, K |
| author_sort | Holloway, C |
| collection | OXFORD |
| description | We postulated that changes in cardiac high-energy phosphate metabolism may underlie the myocardial dysfunction caused by hypobaric hypoxia. Healthy volunteers (n=14) were studied immediately before, and within 4 d of return from, a 17-d trek to Mt. Everest Base Camp (5300 m). (31)P magnetic resonance (MR) spectroscopy was used to measure cardiac phosphocreatine (PCr)/ATP, and MR imaging and echocardiography were used to assess cardiac volumes, mass, and function. Immediately after returning from Mt. Everest, total body weight had fallen by 3% (P<0.05), but left ventricular mass, adjusted for changes in body surface area, had disproportionately decreased by 11% (P<0.05). Alterations in diastolic function were also observed, with a reduction in peak left ventricular filling rates and mitral inflow E/A, by 17% (P<0.05) and 24% (P<0.01), respectively, with no change in hydration status. Compared with pretrek, cardiac PCr/ATP ratio had decreased by 18% (P<0.01). Whether the abnormalities were even greater at altitude is unknown, but all had returned to pretrek levels after 6 mo. The alterations in cardiac morphology, function, and energetics are similar to findings in patients with chronic hypoxia. Thus, a decrease in cardiac PCr/ATP may be a universal response to periods of sustained low oxygen availability, underlying hypoxia-induced cardiac dysfunction in healthy human heart and in patients with cardiopulmonary diseases. |
| first_indexed | 2024-03-06T21:07:43Z |
| format | Journal article |
| id | oxford-uuid:3d0838bb-48d3-4e74-b09b-cfd88acf5ada |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:07:43Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:3d0838bb-48d3-4e74-b09b-cfd88acf5ada2022-03-26T14:17:11ZCardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3d0838bb-48d3-4e74-b09b-cfd88acf5adaEnglishSymplectic Elements at Oxford2011Holloway, CMontgomery, HMurray, ACochlin, LCodreanu, IHopwood, NJohnson, ARider, OLevett, DTyler, DFrancis, JNeubauer, SGrocott, MClarke, KWe postulated that changes in cardiac high-energy phosphate metabolism may underlie the myocardial dysfunction caused by hypobaric hypoxia. Healthy volunteers (n=14) were studied immediately before, and within 4 d of return from, a 17-d trek to Mt. Everest Base Camp (5300 m). (31)P magnetic resonance (MR) spectroscopy was used to measure cardiac phosphocreatine (PCr)/ATP, and MR imaging and echocardiography were used to assess cardiac volumes, mass, and function. Immediately after returning from Mt. Everest, total body weight had fallen by 3% (P<0.05), but left ventricular mass, adjusted for changes in body surface area, had disproportionately decreased by 11% (P<0.05). Alterations in diastolic function were also observed, with a reduction in peak left ventricular filling rates and mitral inflow E/A, by 17% (P<0.05) and 24% (P<0.01), respectively, with no change in hydration status. Compared with pretrek, cardiac PCr/ATP ratio had decreased by 18% (P<0.01). Whether the abnormalities were even greater at altitude is unknown, but all had returned to pretrek levels after 6 mo. The alterations in cardiac morphology, function, and energetics are similar to findings in patients with chronic hypoxia. Thus, a decrease in cardiac PCr/ATP may be a universal response to periods of sustained low oxygen availability, underlying hypoxia-induced cardiac dysfunction in healthy human heart and in patients with cardiopulmonary diseases. |
| spellingShingle | Holloway, C Montgomery, H Murray, A Cochlin, L Codreanu, I Hopwood, N Johnson, A Rider, O Levett, D Tyler, D Francis, J Neubauer, S Grocott, M Clarke, K Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. |
| title | Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. |
| title_full | Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. |
| title_fullStr | Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. |
| title_full_unstemmed | Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. |
| title_short | Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. |
| title_sort | cardiac response to hypobaric hypoxia persistent changes in cardiac mass function and energy metabolism after a trek to mt everest base camp |
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