Inflation vs exhaustion of antiviral CD8+ t-cell populations in persistent infections: two sides of the same coin?

Inflation vs exhaustion of antiviral CD8+ t-cell populations in persistent infections: two sides of the same coin?

Persistent virus infection can drive CD8+ T-cell responses which are markedly divergent in terms of frequency, phenotype, function, and distribution. On the one hand viruses such as Lymphocytic Choriomeningitis Virus (LCMV) Clone 13 can drive T-cell "exhaustion", associated with upregulati...

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Bibliografiske detaljer
Main Authors:	Marchi, E, Lee, L, Klenerman, P
Format:	Journal article
Sprog:	English
Udgivet:	Frontiers Media 2019

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