Single-subject oscillatory gamma responses in tinnitus
This study used magnetoencephalography to record oscillatory activity in a group of 17 patients with chronic tinnitus. Two methods, residual inhibition and residual excitation, were used to bring about transient changes in spontaneous tinnitus intensity in order to measure dynamic tinnitus correlate...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Published: |
Oxford University press
2012
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| _version_ | 1797063990756507648 |
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| author | Sedley, W Teki, S Kumar, S Barnes, G Bamiou, D Griffiths, T |
| author_facet | Sedley, W Teki, S Kumar, S Barnes, G Bamiou, D Griffiths, T |
| author_sort | Sedley, W |
| collection | OXFORD |
| description | This study used magnetoencephalography to record oscillatory activity in a group of 17 patients with chronic tinnitus. Two methods, residual inhibition and residual excitation, were used to bring about transient changes in spontaneous tinnitus intensity in order to measure dynamic tinnitus correlates in individual patients. In residual inhibition, a positive correlation was seen between tinnitus intensity and both delta/theta (6/14 patients) and gamma band (8/14 patients) oscillations in auditory cortex, suggesting an increased thalamocortical input and cortical gamma response, respectively, associated with higher tinnitus states. Conversely, 4/4 patients exhibiting residual excitation demonstrated an inverse correlation between perceived tinnitus intensity and auditory cortex gamma oscillations (with no delta/theta changes) that cannot be explained by existing models. Significant oscillatory power changes were also identified in a variety of cortical regions, most commonly midline lobar regions in the default mode network, cerebellum, insula and anterior temporal lobe. These were highly variable across patients in terms of areas and frequency bands involved, and in direction of power change. We suggest a model based on a local circuit function of cortical gamma-band oscillations as a process of mutual inhibition that might suppress abnormal cortical activity in tinnitus. The work implicates auditory cortex gamma-band oscillations as a fundamental intrinsic mechanism for attenuating phantom auditory perception. |
| first_indexed | 2024-03-06T21:07:53Z |
| format | Journal article |
| id | oxford-uuid:3d14e544-1627-49d6-bbc9-b5f694d780f9 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:07:53Z |
| publishDate | 2012 |
| publisher | Oxford University press |
| record_format | dspace |
| spelling | oxford-uuid:3d14e544-1627-49d6-bbc9-b5f694d780f92022-03-26T14:17:31ZSingle-subject oscillatory gamma responses in tinnitusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3d14e544-1627-49d6-bbc9-b5f694d780f9Symplectic Elements at OxfordOxford University press2012Sedley, WTeki, SKumar, SBarnes, GBamiou, DGriffiths, TThis study used magnetoencephalography to record oscillatory activity in a group of 17 patients with chronic tinnitus. Two methods, residual inhibition and residual excitation, were used to bring about transient changes in spontaneous tinnitus intensity in order to measure dynamic tinnitus correlates in individual patients. In residual inhibition, a positive correlation was seen between tinnitus intensity and both delta/theta (6/14 patients) and gamma band (8/14 patients) oscillations in auditory cortex, suggesting an increased thalamocortical input and cortical gamma response, respectively, associated with higher tinnitus states. Conversely, 4/4 patients exhibiting residual excitation demonstrated an inverse correlation between perceived tinnitus intensity and auditory cortex gamma oscillations (with no delta/theta changes) that cannot be explained by existing models. Significant oscillatory power changes were also identified in a variety of cortical regions, most commonly midline lobar regions in the default mode network, cerebellum, insula and anterior temporal lobe. These were highly variable across patients in terms of areas and frequency bands involved, and in direction of power change. We suggest a model based on a local circuit function of cortical gamma-band oscillations as a process of mutual inhibition that might suppress abnormal cortical activity in tinnitus. The work implicates auditory cortex gamma-band oscillations as a fundamental intrinsic mechanism for attenuating phantom auditory perception. |
| spellingShingle | Sedley, W Teki, S Kumar, S Barnes, G Bamiou, D Griffiths, T Single-subject oscillatory gamma responses in tinnitus |
| title | Single-subject oscillatory gamma responses in tinnitus |
| title_full | Single-subject oscillatory gamma responses in tinnitus |
| title_fullStr | Single-subject oscillatory gamma responses in tinnitus |
| title_full_unstemmed | Single-subject oscillatory gamma responses in tinnitus |
| title_short | Single-subject oscillatory gamma responses in tinnitus |
| title_sort | single subject oscillatory gamma responses in tinnitus |
| work_keys_str_mv | AT sedleyw singlesubjectoscillatorygammaresponsesintinnitus AT tekis singlesubjectoscillatorygammaresponsesintinnitus AT kumars singlesubjectoscillatorygammaresponsesintinnitus AT barnesg singlesubjectoscillatorygammaresponsesintinnitus AT bamioud singlesubjectoscillatorygammaresponsesintinnitus AT griffithst singlesubjectoscillatorygammaresponsesintinnitus |