Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection

Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection

HIV-1 transmission is associated with a severe bottleneck in which a limited number of variants from a pool of genetically diverse quasispecies establishes infection. The IAVI protocol C cohort of discordant couples, female sex workers, other heterosexuals and men who have sex with men (MSM) present...

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Bibliographic Details
Main Authors:	Macharia, GN, Yue, L, Staller, E, Dilernia, D, Wilkins, D, Song, H, McGowan, E, King, D, Fast, P, Imami, N, Price, MA, Sanders, EJ, Hunter, E, Gilmour, J
Format:	Journal article
Language:	English
Published:	Public Library of Science 2020

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