Asian MODY: are we missing an important diagnosis?

Asian MODY: are we missing an important diagnosis?

AIMS: Maturity onset diabetes of the young (MODY) is a monogenic form of diabetes where correct diagnosis alters treatment, prognosis and genetic counselling. The first UK survey of childhood MODY identified 20 White, but no Asian children with MODY. We hypothesized that MODY causes diabetes in UK A...

Full description

Bibliographic Details
Main Authors:	Porter, JR, Rangasami, J, Ellard, S, Gloyn, A, Shields, B, Edwards, J, Anderson, J, Shaw, N, Hattersley, A, Frayling, T, Plunkett, M, Barrett, T
Format:	Journal article
Language:	English
Published:	2006

Similar Items

Permanent neonatal diabetes in an Asian infant.
by: Porter, JR, et al.
Published: (2005)

High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes.
by: McDonald, T, et al.
Published: (2011)

High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes.
by: McDonald, T, et al.
Published: (2011)

The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY
by: Steele, A, et al.
Published: (2011)

The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY.
by: Steele, A, et al.
Published: (2011)

Genetic testing for glucokinase mutations in clinically selected patients with MODY: a worthwhile investment
by: S Schnyder, et al.
Published: (2005-06-01)

Identification of 21 novel glucokinase (GCK) mutations in UK and European Caucasians with maturity-onset diabetes of the young (MODY).
by: Thomson, K, et al.
Published: (2003)

Lipoprotein composition in HNF1A-MODY: differentiating between HNF1A-MODY and type 2 diabetes.
by: McDonald, T, et al.
Published: (2012)

Integration of biomarkers and clinical characteristics provides the best method for identifying patients with MODY
by: Shields, B, et al.
Published: (2012)

When is it MODY? Challenges in the Interpretation of Sequence Variants in MODY Genes
by: Althari, S, et al.
Published: (2016)

Complete glucokinase deficiency is not a common cause of permanent neonatal diabetes.
by: Gloyn, A, et al.
Published: (2002)

The role of the HNF4α enhancer in type 2 diabetes variants of the HNF4α enhancer are not a common cause of susceptibility to type 2 diabetes
by: Mitchell, S, et al.
Published: (2002)

The role of the HNF4alpha enhancer in type 2 diabetes.
by: Mitchell, S, et al.
Published: (2002)

Response to Comment on: McDonald et al. High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes. Diabetes Care 2011;34:1860-1862.
by: McDonald, T, et al.
Published: (2011)

Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype.
by: Flanagan, SE, et al.
Published: (2006)

Catalytic instability of the glucokinase MODY-2 mutants V62M and G72R in pancreatic beta cells
by: Arden, C, et al.
Published: (2006)

Detection of Asian Dust Storm Using MODIS Measurements
by: Yong Xie, et al.
Published: (2017-08-01)

Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.
by: Gloyn, A, et al.
Published: (2006)

Human calcium/calmodulin-dependent protein kinase II gamma gene (CAMK2G): cloning, genomic structure and detection of variants in subjects with type II diabetes.
by: Gloyn, A, et al.
Published: (2002)

Defining the genetic aetiology of monogenic diabetes can improve treatment.
by: Gloyn, A, et al.
Published: (2006)

Calcium/calmodulin dependent protein kinase II genes: Genomic structure and screening for variants in subjects with Type 2 diabetes
by: Gloyn, A, et al.
Published: (2001)

Origin of de novo KCNJ11 mutations and risk of neonatal diabetes for subsequent siblings.
by: Edghill, E, et al.
Published: (2007)

Mutations in HHEX are not a common cause of monogenic forms of beta cell dysfunction.
by: Minton, J, et al.
Published: (2007)

Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2.
by: Weedon, M, et al.
Published: (2003)

Large-scale type 2 diabetes association analysis of low-frequency nonsynonymous coding variants in the HNF4A gene including up to 17,600 individuals
by: Mohammadi, B, et al.
Published: (2008)

Advertising in medical journals: Are we missing the point?
by: Pierre J.T. de Villiers
Published: (2011-07-01)

Maturity-onset diabetes of the young caused by a balanced translocation where the 20q12 break point results in disruption upstream of the coding region of hepatocyte nuclear factor-4alpha (HNF4A) gene.
by: Gloyn, A, et al.
Published: (2002)

Role of low frequency variants in HNF1A exons 8-10 encoding hepatocyte nuclear factor-1 alpha isoform A to susceptibility to Type 2 diabetes
by: Jafar-Mohammadi, B, et al.
Published: (2010)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to Type 2 diabetes
by: Jafar-Mohammadi, B, et al.
Published: (2009)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.
by: Jafar-Mohammadi, B, et al.
Published: (2009)

Identification and functional characterisation of novel inactivating glucokinase mutations causing GCK-MODY in Slovakia
by: Valentinova, L, et al.
Published: (2011)

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
by: Wiltshire, S, et al.
Published: (2004)

KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features.
by: Gloyn, A, et al.
Published: (2006)

Metodologie i mody metodologiczne we współczesnej humanistyce (literaturoznawczej)
by: Stanisław Balbus
Published: (2007-02-01)

Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance
by: Kashyap A. Patel, et al.
Published: (2017-10-01)

Canaliculitis: Are we missing the diagnosis?
by: Abdullah Al-Mujaini, et al.
Published: (2009-01-01)

What We’re Missing
by: Camille R. Whitney, et al.
Published: (2017-04-01)

The Importance of Secondary Gain - a Missing Story
by: J. Wise
Published: (2022-06-01)

Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel.
by: Gloyn, A, et al.
Published: (2004)

Erratum: Mutations in ATP-sensitive K+ cannel genes cause transient neonatal diabetes and permanent diabetes in childhood or adulthood (Diabetes (2007) 56 (1930-1937))
by: Flanagan, SE, et al.
Published: (2008)