Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans.
In humans, the kinetics of the appearance of memory B cells and plasma cells during primary immunization are not well defined. In this study, we assessed the primary B-cell response of rabies-antigen naive volunteers during a 3-dose course of rabies vaccine compared with the B-cell response to a boo...
| Auteurs principaux: | , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
2009
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| _version_ | 1826268360162148352 |
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| author | Blanchard-Rohner, G Pulickal, A Jol-van der Zijde, C Snape, MD Pollard, A |
| author_facet | Blanchard-Rohner, G Pulickal, A Jol-van der Zijde, C Snape, MD Pollard, A |
| author_sort | Blanchard-Rohner, G |
| collection | OXFORD |
| description | In humans, the kinetics of the appearance of memory B cells and plasma cells during primary immunization are not well defined. In this study, we assessed the primary B-cell response of rabies-antigen naive volunteers during a 3-dose course of rabies vaccine compared with the B-cell response to a booster dose of rabies vaccine given to previously immunized volunteers. After a single dose of vaccine, in the naive group plasma and memory B cells appeared later (peak at day 10) than in the primed group (peak at day 7) and were at lower frequency. The most rapid responses (day 4) were detected after a third immunization in the naive group. This is the first study to document the detailed kinetics of the plasma cell and memory B-cell responses to immunization in adult humans and to demonstrate differences in the responses that relate to the preexisting immune status of the persons. |
| first_indexed | 2024-03-06T21:08:30Z |
| format | Journal article |
| id | oxford-uuid:3d50d4b2-67db-4ab8-99d6-aee4a7b2c020 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:08:30Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:3d50d4b2-67db-4ab8-99d6-aee4a7b2c0202022-03-26T14:18:42ZAppearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3d50d4b2-67db-4ab8-99d6-aee4a7b2c020EnglishSymplectic Elements at Oxford2009Blanchard-Rohner, GPulickal, AJol-van der Zijde, CSnape, MDPollard, AIn humans, the kinetics of the appearance of memory B cells and plasma cells during primary immunization are not well defined. In this study, we assessed the primary B-cell response of rabies-antigen naive volunteers during a 3-dose course of rabies vaccine compared with the B-cell response to a booster dose of rabies vaccine given to previously immunized volunteers. After a single dose of vaccine, in the naive group plasma and memory B cells appeared later (peak at day 10) than in the primed group (peak at day 7) and were at lower frequency. The most rapid responses (day 4) were detected after a third immunization in the naive group. This is the first study to document the detailed kinetics of the plasma cell and memory B-cell responses to immunization in adult humans and to demonstrate differences in the responses that relate to the preexisting immune status of the persons. |
| spellingShingle | Blanchard-Rohner, G Pulickal, A Jol-van der Zijde, C Snape, MD Pollard, A Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans. |
| title | Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans. |
| title_full | Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans. |
| title_fullStr | Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans. |
| title_full_unstemmed | Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans. |
| title_short | Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans. |
| title_sort | appearance of peripheral blood plasma cells and memory b cells in a primary and secondary immune response in humans |
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