Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo.

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo.

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Posttranslational modification by ubiquitin controls multiple cellular functions and is counteracted by the activities of deubiquitinating enzymes. UBPy (USP8) is a growth-regulated ubiquitin isopeptidase that interacts with the HRS-STAM complex. Using Cre-loxP-mediated gene targeting in mice, we sh...

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Dettagli Bibliografici
Autori principali:	Niendorf, S, Oksche, A, Kisser, A, Löhler, J, Prinz, M, Schorle, H, Feller, S, Lewitzky, M, Horak, I, Knobeloch, K
Natura:	Journal article
Lingua:	English
Pubblicazione:	2007

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