Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.

Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.

Cytotoxic T lymphocytes (CTL) can respond to a few viral peptide-MHC-I (pMHC-I) complexes among a myriad of virus-unrelated endogenous self pMHC-I complexes displayed on virus-infected cells. To elucidate the molecular recognition events on live CTL, we have utilized a self-assembled biosensor compo...

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Bibliographic Details
Main Authors:	Anikeeva, N, Lebedeva, T, Clapp, A, Goldman, E, Dustin, M, Mattoussi, H, Sykulev, Y
Format:	Journal article
Language:	English
Published:	2006

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